ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2014
Living with cancer-related uncertainty: associations with fatigue, insomnia, and affect in younger breast cancer survivors.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Efficacy of cognitive behavioral therapy for insomnia in breast cancer: A meta-analysis.Sleep medicine reviews · 2021Pooled it
- Mind-body interventions for fear of cancer recurrence: A systematic review and meta-analysis.Psycho-oncology · 2018Pooled it
- Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC]).Translational behavioral medicine · 2019Trial
- Effectiveness of Two Web-Based Interventions for Chronic Cancer-Related Fatigue Compared to an Active Control Condition: Results of the "Fitter na kanker" Randomized Controlled Trial.Journal of medical Internet research · 2017Trial
- Mindfulness-Based Stress Reduction in Post-treatment Breast Cancer Patients: Immediate and Sustained Effects Across Multiple Symptom Clusters.Journal of pain and symptom management · 2017Trial
- Pain-Related Dysfunctional Beliefs About Sleep and Depression Mediate the Influence of Pain Severity on Fear of Progression Among Individuals With Cancer.Psychiatry investigation · 2026Article
- Symptom burden in cancer survivorship: insights from a survivorship program's patient-reported outcomes database.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Factors associated with sleep disturbance in breast cancer survivors over time.The oncologist · 2025Article
- Managing, not lessening, uncertainty: a novel mind-body intervention for fear of cancer recurrence.Journal of cancer survivorship : research and practice · 2025Article
- Prediction of Sleep Quality in Cancer Survivors Based on Arousal, Pain, and Worry: The Mediating Role of Dysfunctional Beliefs and Attitudes About Sleep.Cancer medicine · 2025Article
- Cancer prognosis information-seeking among survivors and caregivers: findings from the National Cancer Institute's Cancer Information Service.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Factors affecting return to work in breast cancer survivors in Korea: a cross-sectional study.Women's health nursing (Seoul, Korea) · 2024Article
- The relationship between uncertainty and fear of disease progression among newly diagnosed cancer patients: the mediating role of intolerance of uncertainty.BMC psychiatry · 2024Article
- Exercise Intervention on Insomnia in Patients with a Cancer: A Systematic Review of the Literature.Cancers · 2024Review
- Uncertainty affects cancer-related fatigue among breast cancer women undergoing peripherally inserted central catheter chemotherapy: the chain mediating role of psychological resilience and self-care.BMC women's health · 2024Article
- Setting the Stage for Cancer: Stay Soft and Optimistic.The Yale journal of biology and medicine · 2024Review
- From existential uncertainty to a new mindset promoting recovery: Exploring the development of uncertainty experience in women with vulvar neoplasia - A qualitative longitudinal study.BMC women's health · 2024Article
- A data-driven approach to improve wellness and reduce recurrence in cancer survivors.Frontiers in oncology · 2024Article
- Distress, Pain, and Coping Strategies in Patients Undergoing Breast-Conserving Surgery: A Scoping Literature Review.Oncology nursing forum · 2023Article
- The bodily threat monitoring scale: Development and preliminary validation in adult and childhood cancer survivors.Psycho-oncology · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeUncertainty in cancer patients and survivors about cancer-related symptoms, treatment, and disease course has been related to poorer mental and physical health. However, little is known about whether cancer-related uncertainty relates with specific disease and treatment-related outcomes such as fatigue, insomnia, and affect disruptions. In this paper, we report these associations in younger survivors aged 50 years or less, a population increasing in prevalence.
methodsParticipants included 313 breast cancer survivors (117 African-Americans and 196 Caucasians) who were aged 24 to 50 years and were 2 to 4 years posttreatment. Self-reported cancer-related uncertainty (Mishel Uncertainty in Illness Scale-Survivor Version), fatigue (Piper Fatigue Scale-Revised), insomnia (Insomnia Severity Index), and negative and positive affect (Positive and Negative Affect Schedule (PANAS)) measures were collected upon study entry.
resultsHierarchical regression analyses controlled for relevant sociodemographic variables include the following: race, age, years of education, number of children, employment status, marital status, monthly income, smoking status, family history of cancer, endorsement of treatment-induced menopause, and religiosity. Over and above these factors, higher cancer-related uncertainty was significantly associated with more self-reported fatigue (β = .43), insomnia (β = .34), negative affect (β = .43), as well as less positive affect (β = -.33), all ps < .01.
conclusionsYounger breast cancer survivors who are 2-4 years posttreatment experience cancer-related uncertainty, with higher levels associated with more self-reported psychophysiological disruptions. Cancer survivors who present in clinical settings with high uncertainty about recurrence or management of long-term effects of treatment may thus benefit from assessment of fatigue, insomnia, and affect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.