ArticleInflammation2014
Human peripheral neutrophils express functional IL-21 receptors.
Article in Inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- IL-21-dependent Ly6CCell death discovery · 2025Article
- Intracellular Major Histocompatibility Complex Class II and C-X-C Motif Chemokine Ligand 10-Expressing Neutrophils Indicate the State of Anti-Tumor Activity Induced byBiomedicines · 2023Article
- Initial Myeloid Cell Status Is Associated with Clinical Outcomes of Renal Cell Carcinoma.Biomedicines · 2023Article
- GPI-80 Augments NF-κB Activation in Tumor Cells.International journal of molecular sciences · 2021Article
- IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses toeLife · 2019Article
- IL-21 promotes myocardial ischaemia/reperfusion injury through the modulation of neutrophil infiltration.British journal of pharmacology · 2018Article
- Relationship between Immunological Abnormalities in Rat Models of Diabetes Mellitus and the Amplification Circuits for Diabetes.Journal of diabetes research · 2017Review
- The pattern of GPI-80 expression is a useful marker for unusual myeloid maturation in peripheral blood.Clinical and experimental immunology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils play key roles in the inflammatory response. The IL-21 cytokine and receptor system is known to be involved in various inflammatory diseases. However, the direct action of IL-21 on neutrophils has not been reported. Here, we show that human neutrophils in peripheral blood express functional IL-21 receptors (IL-21Rs). Expression of the IL-21Rα chain (IL-21Rα) was reduced following various treatments to remove red blood cells, including hypotonic shock, ammonium chloride-mediated lysis, and Percoll density centrifugation. Thus, we utilized whole blood flow cytometric assays to investigate the neutrophil responses to IL-21. IL-21 upregulated the surface expression of CD11b and CD16 on neutrophils and augmented the neutrophils' phagocytic ability. Our data indicated that IL-21 has the potential to enhance the neutrophil functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.