SynthesisPloS one2014
A meta-analysis of the diagnostic accuracy of two commercial NS1 antigen ELISA tests for early dengue virus detection.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic accuracy of clinical signs and symptoms of COVID-19: A systematic review and meta-analysis to investigate the different estimates in a different stage of the pandemic outbreak.Journal of global health · 2023Pooled it
- Severe Acute Respiratory Syndrome Coronavirus 2 Diagnostic Tests for Border Screening During the Very Early Phase of Coronavirus Disease 2019 Pandemic: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- A rapid multiplex platform for simultaneous detection of chikungunya virus, dengue virus, and dengue serotyping based on isothermal amplification and lateral flow dipsticks.Infectious diseases of poverty · 2026Article
- Dengue: epidemiology, diagnosis methods, treatment options, and prevention strategies.Archives of virology · 2025Review
- Clinical characteristics of dengue virus infections in Karachi from 2019 to 2023: a cross-sectional study.Scientific reports · 2024Article
- Aptamer-associated colorimetric reverse transcription loop-mediated isothermal amplification assay for detection of dengue virus.Microbiology spectrum · 2024Article
- Dengue: A review of laboratory diagnostics in the vaccine age.Journal of medical microbiology · 2024Review
- Article
- Genetic characterization of dengue virus serotype 1 circulating in Reunion Island, 2019-2021, and the Seychelles, 2015-2016.BMC infectious diseases · 2023Article
- First Report of the Detection of DENV1 in Human Blood Plasma with Near-Infrared Spectroscopy.Viruses · 2022Article
- Non-structural protein 1 (NS1) variants from dengue virus clinical samples revealed mutations that influence NS1 production and secretion.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- A Rapid and Easy-to-Perform Method of Nucleic-Acid Based Dengue Virus Diagnosis Using Fluorescence-Based Molecular Beacons.Biosensors · 2021Article
- Development and Performance of Dengue Diagnostic Clinical Algorithms in Colombia.The American journal of tropical medicine and hygiene · 2020Article
- The inability of a dengue NS1 ELISA to detect Zika infections.Scientific reports · 2019Observational
- A review of dengue diagnostics and implications for surveillance and control.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019Review
- Development and characterization of serotype-specific monoclonal antibodies against the dengue virus-4 (DENV-4) non-structural protein (NS1).Virology journal · 2018Article
- Prospective evaluation of the SD BIOLINE Dengue Duo rapid test during a dengue virus epidemic.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Increased sensitivity of NS1 ELISA by heat dissociation in acute dengue 4 cases.BMC infectious diseases · 2017Article
- Clinical Utility of the Nonstructural 1 Antigen Rapid Diagnostic Test in the Management of Dengue in Returning Travelers With Fever.Open forum infectious diseases · 2017Article
- Accuracy of clinical criteria and an immunochromatographic strip test for dengue diagnosis in a DENV-4 epidemic.BMC infectious diseases · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue virus (DENV) NS1 antigen detection is regarded as an early diagnostic marker. Accordingly, several studies have evaluated the performance of tests that utilize NS1 capture, but the results of individual studies may be limited due to the restricted sample size of the patients recruited. Therefore, our objective was to perform a meta-analysis of the diagnostic accuracy of two commercial NS1 ELISAs (Panbio and Platelia). METHODS AND
resultsStudies of interest were found in PubMed, Embase and Google Scholar databases using defined inclusion/exclusion criteria. A total of 30 studies containing 12,105 total enrolled patients were included. The results were as follows: 1) Panbio assays showed low overall performance, sensitivity 66% (95% confidence interval (CI) 61-71), specificity 99% (95% CI 96-100), positive likelihood ratio (LR+) 98 (95% CI 20-464), negative likelihood ratio (LR-) 0.3 (95% CI 0.2-0.4), diagnostic odds ratio (DOR) 289 (95% CI 59-1412); 2) Platelia assays showed high overall performance, sensitivity 74% (95% CI 63-82), specificity 99% (95% CI 97-100), LR+ 175 (95% CI 28-1099), LR- 0.3 (95% CI 0.2-0.4), DOR 663 (95% CI 98-4478). The lowest sensitivity values were for secondary infections (57% [95% CI 47-67] and 66% [95% CI 53-77] for Panbio and Platelia, respectively) and for the detection of DENV4. Regarding clinical manifestations, the sensitivity of Platelia was 69% (95% CI 43-86) and 60% (95% CI 48-70) for fever and dengue hemorrhagic fever, respectively. In addition, the sensitivity of both tests was slightly lower for samples from Southeast Asia and Oceania.
conclusionDENV1 samples gave higher sensitivity results for both tests. We observed that factors negatively influencing the tests, such as the type of infection, geographical origins of samples and viral serotypes, require further investigation to optimize the diagnostic accuracy.
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