Evidence map›Paper›PMID 24728352›Full record

ArticleNature immunology2014

A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla.

Mathias Hauri-Hohl, Saulius Zuklys, Georg A Holländer, Steven F Ziegler

Abstract read
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In one paragraph

Article in Nature immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  17. Frontiers in cell and developmental biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mathias Hauri-HohlImmunology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA.
Saulius Zuklys1] Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland. [2] Basel University's Hospital, Basel, Switzerland.
Georg A Holländer1] Laboratory of Pediatric Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland. [2] Basel University's Hospital, Basel, Switzerland. [3] Developmental Immunology, Department of Pediatrics, University of Oxford, Oxford, UK. [4] These authors contributed equally to this work.
Steven F Ziegler1] Immunology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA. [2] These authors contributed equally to this work.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medullary thymic epithelial cells (mTECs) are critical in establishing and maintaining the appropriate microenvironment for negative selection and maturation of immunocompetent T cells with a self-tolerant T cell antigen receptor repertoire. Cues that direct proliferation and maturation of mTECs are provided by members of the tumor necrosis factor (TNF) superfamily expressed on developing thymocytes. Here we demonstrate a negative role of the morphogen TGF-β in tempering these signals under physiological conditions, limiting both growth and function of the thymic medulla. Eliminating TGF-β signaling specifically in TECs or by pharmacological means increased the size of the mTEC compartment, enhanced negative selection and functional maturation of medullary thymocytes as well as the production of regulatory T cells, thus reducing the autoreactive potential of peripheral T cells.

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationCells, CulturedCellular MicroenvironmentDNA-Binding ProteinsEpithelial CellsLymphocyte ActivationMiceMice, Inbred C57BLMice, TransgenicProtein Serine-Threonine KinasesProto-Oncogene Proteins c-mycReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IIDNA-Binding ProteinsMyc protein, mouseProtein Serine-Threonine KinasesProto-Oncogene Proteins c-mycRag2 protein, mouseReceptors, Transforming Growth Factor betaReceptor, Transforming Growth Factor-beta Type IITransforming Growth Factor betaTumor Necrosis Factor-alpha

Identifiers

PMID24728352

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.