ArticlePloS one2014
The pattern of cytokine production in vitro induced by ancient and modern Beijing Mycobacterium tuberculosis strains.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Lineage-Dependent IFN-γ Responses to Drug-Sensitive and Isoniazid-ResistantInfection and drug resistance · 2026Article
- Article
- The Mycobacterium tuberculosis genome at 25 years: lessons and lingering questions.The Journal of clinical investigation · 2023Review
- Modern Beijing sublineage ofEmerging microbes & infections · 2022Article
- Multidrug-Resistant Tuberculosis-Diagnostic Procedures and Treatment of Two Beijing-like TB Cases.Diagnostics (Basel, Switzerland) · 2022Article
- Association of Mannose-Binding Lectin 2 Gene Polymorphism with Tuberculosis Based onInfection and drug resistance · 2022Article
- Profiling the immune response toVirulence · 2021Article
- Whole-genome comparative analysis at the lineage/sublineage level discloses relationships betweenPeerJ · 2021Article
- Genetic Diversity inAnnual review of genetics · 2020Review
- Circulation ofPathogens and global health · 2019Review
- Vitamin D modulates human macrophage response to Mycobacterium tuberculosis DNA.Tuberculosis (Edinburgh, Scotland) · 2019Article
- Review
- Evidence for Host-Bacterial Co-evolution via Genome Sequence Analysis of 480 Thai Mycobacterium tuberculosis Lineage 1 Isolates.Scientific reports · 2018Article
- Virulence ofFrontiers in cellular and infection microbiology · 2018Article
- Pathogen lineage-based genome-wide association study identified CD53 as susceptible locus in tuberculosis.Journal of human genetics · 2017Article
- Transmissible Mycobacterium tuberculosis Strains Share Genetic Markers and Immune Phenotypes.American journal of respiratory and critical care medicine · 2017Article
- Draft Genome Sequence of Mycobacterium tuberculosis Clinical Strain W06, a Prevalent Beijing Genotype Isolated in Taiwan.Genome announcements · 2015Article
- The microbiome at the pulmonary alveolar niche and its role in Mycobacterium tuberculosis infection.Tuberculosis (Edinburgh, Scotland) · 2015Review
- Southern East Asian origin and coexpansion of Mycobacterium tuberculosis Beijing family with Han Chinese.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Correlates between models of virulence for Mycobacterium tuberculosis among isolates of the Central Asian lineage: a case for lysozyme resistance testing?Infection and immunity · 2015Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
It is unclear to what extent the host-responses elicited by Beijing versus non-Beijing strains of Mycobacterium tuberculosis (MTB) contribute to the predominance of modern Beijing strains in Taiwan and some other Asian countries. The purpose of this study was to compare the expression profiles of virulence-related genes in human monocyte-derived macrophages infected in vitro with Beijing (ancient and modern strains) and non-Beijing strains (EAI strains) of MTB that are epidemic in Taiwan. We found that modern Beijing strains induced lower levels of pro-inflammatory cytokines, whereas EAI strains induced higher levels. Notably, the most prevalent modern Beijing sub-lineage, possessing intact RD150 and RD142 chromosomal regions, induced very low levels of pro-inflammatory cytokines, especially interleukin-1β. Moreover, in an intracellular growth assay, the survival of the same modern Beijing strain in human monocyte-derived macrophages was significantly higher than that of an ancient Beijing strain and an EAI strain. Taken together, these results may explain why modern Beijing strains of MTB predominate in Taiwan.
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