ReviewInternational orthopaedics2014
Percutaneous grafting with bone marrow autologous concentrate for open tibia fractures: analysis of forty three cases and literature review.
Review in International orthopaedics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- Local transplantation of bone marrow concentrated granulocytes precursors can cure without antibiotics infected nonunion of polytraumatic patients in absence of bone defect.International orthopaedics · 2016Trial
- Significantly increased bone volume in a critical-sized defect model in the rat animal model by transplantation of a stand-alone vascularized periosteal flap.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Regional Gene Therapy for Bone Tissue Engineering: A Current Concepts Review.Bioengineering (Basel, Switzerland) · 2025Review
- Long bone uninfected non-union: grafting techniques.EFORT open reviews · 2024Review
- Treatment options for aseptic tibial diaphyseal nonunion: A review of selected studies.EFORT open reviews · 2020Review
- Frontiers in non-union research.EFORT open reviews · 2020Review
- Systematic review assessing the evidence for the use of stem cells in fracture healing.Bone & joint open · 2020Article
- Ceramic Scaffolds in a Vacuum Suction Handle for Intraoperative Stromal Cell Enrichment.International journal of molecular sciences · 2020Article
- The Treatment of Acute Diaphyseal Long-bones Fractures with Orthobiologics and Pharmacological Interventions for Bone Healing Enhancement: A Systematic Review of Clinical Evidence.Bioengineering (Basel, Switzerland) · 2020Review
- Mechanistic role of perfusion culture on bone regeneration.Journal of biosciences · 2019Review
- Mesenchymal Stromal Cell-Based Bone Regeneration Therapies: From Cell Transplantation and Tissue Engineering to Therapeutic Secretomes and Extracellular Vesicles.Frontiers in bioengineering and biotechnology · 2019Review
- Scaffolds as Structural Tools for Bone-Targeted Drug Delivery.Pharmaceutics · 2018Review
- Rapid Osteogenic Enhancement of Stem Cells in Human Bone Marrow Using a Glycogen-Synthease-Kinase-3-Beta Inhibitor Improves Osteogenic Efficacy In Vitro and In Vivo.Stem cells translational medicine · 2018Article
- Percutaneous autologous bone marrow transplantation for the treatment of delayed union of limb bone in children.Therapeutics and clinical risk management · 2018Article
- The Components of Bone and What They Can Teach Us about Regeneration.Materials (Basel, Switzerland) · 2017Review
- Clinical application of concentrated bone marrow aspirate in orthopaedics: A systematic review.World journal of orthopedics · 2017Article
- Human autologous mesenchymal stem cells with extracorporeal shock wave therapy for nonunion of long bones.Indian journal of orthopaedics · 2016Article
- Osteogenic progenitors in bone marrow aspirates have clinical potential for tibial non-unions healing in diabetic patients.International orthopaedics · 2016Article
- Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes.International orthopaedics · 2015Article
- Ilizarov bone transport combined with antibiotic cement spacer for infected tibial nonunion.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTibial fractures are the most common lower limb fractures. Some criteria such as open fractures and increasing open stage are known to be associated with high delayed union and pseudarthrosis rate. In cases of delayed or nonunion, classical treatment is autologous cancelous bone graft which is associated with high morbidity rate. The ideal treatment would be a percutaneous harvesting and grafting technique. As bone marrow autologous concentrate (BMAC) presents both advantages, we evaluated this technique from 2002 to 2007.
methodsThis was a retrospective study of 43 cases of open tibial fractures with initial surgical treatment. The criteria of inclusion were open fracture and nonunion, delayed union or suspicion of delayed union.
resultsIn 23 cases (53.5 %) BMAC was successful. The success group had received significantly more CFU-F than the failure group (469 vs 153.10(3), p = 0.013). A threshold of 360.10(3) CFU-F grafted could be established over which there was 100 % success. BMAC done before 110 days after fracture had 47 % success and BMAC done since 110 days after fracture had 73 % success. BMAC success rate decreased with increasing initial fracture skin open stage. There was no BMAC success in cases of a fracture with a remaining gap of more than 4 mm. We had no complications with the technique at the iliac harvesting zone and tibia injection point.
conclusionBMAC is a technique that should be considered as one of the different alternatives for management of long-bone delayed and nonunion because of its effectiveness, low complication rate, preservation of bone stock and low cost.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.