Evidence map›Paper›PMID 24728292›Full record

ArticleNature genetics2014

Heritability and genomics of gene expression in peripheral blood.

Fred A Wright, Patrick F Sullivan, Andrew I Brooks, Fei Zou, Wei Sun, Kai Xia, Vered Madar, Rick Jansen, Wonil Chung, Yi-Hui Zhou and 29 more

Open access · greenAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
229citing papers in PubMed, 15 pooled it
32.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

229 citing papers in PubMed, 15 syntheses or guidelines pooled it, 413 citations in OpenAlex.

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169 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 5 institutions in 2 countries.

Fred A Wright1] Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA. [2] Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA. [3] Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA. [4].
Patrick F Sullivan1] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. [2].ORCID 000000026619873X
Andrew I BrooksDepartment of Genetics, Rutgers University, New Brunswick, New Jersey, USA.
Fei ZouDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Wei SunDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kai XiaDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Vered MadarDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Rick JansenDepartment of Psychiatry, VU Medical Center, Amsterdam, The Netherlands.
Wonil ChungDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Yi-Hui Zhou1] Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA. [2] Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA.
Abdel AbdellaouiDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Sandra BatistaDepartment of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Casey ButlerDepartment of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Guanhua ChenDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000000293142037
Ting-Huei ChenDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
David D'AmbrosioEnvironmental and Occupational Health Sciences Institute, Rutgers University, New Brunswick, New Jersey, USA.
Paul GallinsDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Min Jin HaDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jouke Jan HottengaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Shunping HuangDepartment of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Mathijs KattenbergDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Jaspreet KocharEnvironmental and Occupational Health Sciences Institute, Rutgers University, New Brunswick, New Jersey, USA.
Christel M MiddeldorpDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Ani QuEnvironmental and Occupational Health Sciences Institute, Rutgers University, New Brunswick, New Jersey, USA.
Andrey ShabalinDepartment of Pharmacotherapy and Outcomes Science, Virginia Commonwealth University, Richmond, Virginia, USA.
Jay TischfieldDepartment of Genetics, Rutgers University, New Brunswick, New Jersey, USA.
Laura ToddDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jung-Ying Tzeng1] Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA. [2] Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA.
Gerard van GrootheestDepartment of Psychiatry, VU Medical Center, Amsterdam, The Netherlands.
Jacqueline M VinkDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Qi WangEnvironmental and Occupational Health Sciences Institute, Rutgers University, New Brunswick, New Jersey, USA.
Wei WangDepartment of Computer Science, University of California, Los Angeles, Los Angeles, California, USA.
Weibo WangDepartment of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Gonneke WillemsenDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Johannes H SmitDepartment of Psychiatry, VU Medical Center, Amsterdam, The Netherlands.
Eco J de GeusDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
Zhaoyu YinDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Brenda W J H PenninxDepartment of Psychiatry, VU Medical Center, Amsterdam, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, VU University, Amsterdam, The Netherlands.
University of North Carolina at Chapel Hill · USRutgers, The State University of New Jersey · USAmsterdam UMC Location Vrije Universiteit Amsterdam · NLNorth Carolina State University · USVirginia Commonwealth University · US

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
STOCHASTIC ANALYSIS OF FLOW AND TRANSPORT PHENOMENAP42ES005948 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA · 1992 to 2017
$45.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Integration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5M
Research Education in Statistical Genetics of Substance AbuseR25DA026119 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEALE, MICHAEL CHURTON · 2008 to 2018
$3.2M
Robust Methods for Complex Trait Mapping with Collaborative CrossR01GM074175 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZOU, FEI · 2006 to 2014
$1.7M
Systems approaches to link tissue-specific expression to diseaseR01MH101819 · NIMH · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI NOBEL, ANDREW B, WRIGHT, FRED A. · 2013 to 2015
$1.3M
FACILITATING GTEx, DISEASE, AND GxE ANALYSES VIA FAST EXPRESSION (e)QTL MAPPINGR01MH090936 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NOBEL, ANDREW B, RUSYN, IVAN · 2010 to 2012
$847k
European Research Council 230374NCI NIH HHS P30 CA016086NIDA NIH HHS R25 DA026119NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P42 ES005948NIGMS NIH HHS R01 GM074175NIMH NIH HHS R01 MH090936NIMH NIH HHS R01 MH101819NIMH NIH HHS RC2 MH089951NIMH NIH HHS U24 MH068457
6 · The paper itself

Abstract

We assessed gene expression profiles in 2,752 twins, using a classic twin design to quantify expression heritability and quantitative trait loci (eQTLs) in peripheral blood. The most highly heritable genes (∼777) were grouped into distinct expression clusters, enriched in gene-poor regions, associated with specific gene function or ontology classes, and strongly associated with disease designation. The design enabled a comparison of twin-based heritability to estimates based on dizygotic identity-by-descent sharing and distant genetic relatedness. Consideration of sampling variation suggests that previous heritability estimates have been upwardly biased. Genotyping of 2,494 twins enabled powerful identification of eQTLs, which we further examined in a replication set of 1,895 unrelated subjects. A large number of non-redundant local eQTLs (6,756) met replication criteria, whereas a relatively small number of distant eQTLs (165) met quality control and replication standards. Our results provide a new resource toward understanding the genetic control of transcription.

Indexed as

BloodGene Expression ProfilingGene Expression RegulationGenotypeHumansInheritance PatternsLikelihood FunctionsNetherlandsPolymorphism, Single NucleotideQuantitative Trait Loci

Identifiers

PMID24728292
PMCPMC4012342
OpenAlexW2085126855

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.