Evidence map›Paper›PMID 24728268›Full record

ArticleNature neuroscience2014

Volitional modulation of optically recorded calcium signals during neuroprosthetic learning.

Kelly B Clancy, Aaron C Koralek, Rui M Costa, Daniel E Feldman, Jose M Carmena

Abstract read
In one paragraph

Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed.

  1. MEG-BMI to Control Phantom Limb Pain.Neurologia medico-chirurgica · 2018
    Trial
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  10. Functional reorganization of motor cortex connectivity during learning.bioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. Article
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  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kelly B Clancy *Biophysics Program, UC Berkeley, University of California, Berkeley.
Aaron C Koralek *Helen Wills Neuroscience Institute, UC Berkeley, University of California, Berkeley.
Rui M CostaChampalimaud Neuroscience Programme Champalimaud Center for the Unknown, Lisbon, Portugal.
Daniel E FeldmanHelen Wills Neuroscience Institute, UC Berkeley, University of California, Berkeley.
Jose M CarmenaHelen Wills Neuroscience Institute, UC Berkeley, University of California, Berkeley.

Funding

Neural Mechanisms of Tactile Sensation in Rodent Somatosensory CortexR01NS072416 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI FELDMAN, DANIEL · 2010 to 2014
$1.3M
European Research Council 243393NINDS NIH HHS 1R01NS072416-01NINDS NIH HHS R01 NS072416
6 · The paper itself

Abstract

Brain-machine interfaces are not only promising for neurological applications, but also powerful for investigating neuronal ensemble dynamics during learning. We trained mice to operantly control an auditory cursor using spike-related calcium signals recorded with two-photon imaging in motor and somatosensory cortex. Mice rapidly learned to modulate activity in layer 2/3 neurons, evident both across and within sessions. Learning was accompanied by modifications of firing correlations in spatially localized networks at fine scales.

Indexed as

Brain-Computer InterfacesMicroscopy, Fluorescence, MultiphotonAction PotentialsAnimalsCalcium SignalingCerebral CortexLearningMaleMiceMice, Inbred C57BLVolition

Identifiers

PMID24728268
PMCPMC4361947

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.