ArticlePloS one2014
Cognitive control in opioid dependence and methadone maintenance treatment.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Effects of Exercise on Neural Changes in Inhibitory Control: An ALE Meta-Analysis of fMRI Studies.Frontiers in human neuroscience · 2022Pooled it
- Meta-analysis of aberrant post-error slowing in substance use disorder: implications for behavioral adaptation and self-control.The European journal of neuroscience · 2019Pooled it
- Measurement of Impulsivity and Its Role in Drug Use Behaviours and Related Health, Harm and Treatment Outcomes Among People Who Use Illicit Drugs-A Scoping Review.International journal of mental health and addiction · 2026Article
- The difference in the effect of methadone and protracted abstinence on the coupling among key large-scale brain networks of individuals with heroin use disorder: A resting-state fMRI study.Psychological medicine · 2025Article
- Cognitive control in individuals with heroin use disorder after prolonged methadone maintenance treatment.BMC psychiatry · 2025Article
- Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder.JAMA network open · 2025Article
- Preliminary Evidence of the Association between Time on Buprenorphine and Cognitive Performance among Individuals with Opioid Use Disorder Maintained on Buprenorphine: A Pilot Study.International journal of environmental research and public health · 2023Article
- Neurocognitive Impulsivity in Opiate Users at Different Lengths of Abstinence.International journal of environmental research and public health · 2023Article
- The Neural Signature of Impaired Inhibitory Control in Individuals with Heroin Use Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Attentional function and inhibitory control in different substance use disorders.Psychiatry research · 2022Article
- Effects of exposureToxicology reports · 2022Article
- Altered functional network activities for behavioral adjustments and Bayesian learning in young men with Internet gaming disorder.Journal of behavioral addictions · 2021Article
- Prior cocaine self-administration impairs attention signals in anterior cingulate cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Impact of Substance Use Disorder Pharmacotherapy on Executive Function: A Narrative Review.Frontiers in psychiatry · 2019Review
- Acute Exercise Facilitates the N450 Inhibition Marker and P3 Attention Marker during Stroop Test in Young and Older Adults.Journal of clinical medicine · 2018Article
- Longitudinal behavioral and fMRI-based assessment of inhibitory control in heroin addicts on methadone maintenance treatment.Experimental and therapeutic medicine · 2018Article
- Age and impulsive behavior in drug addiction: A review of past research and future directions.Pharmacology, biochemistry, and behavior · 2018Review
- Pathological gambling: a review of the neurobiological evidence relevant for its classification as an addictive disorder.Addiction biology · 2017Review
- Neural and behavioral mechanisms of proactive and reactive inhibition.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- A dual but asymmetric role of the dorsal anterior cingulate cortex in response inhibition and switching from a non-salient to salient action.NeuroImage · 2016Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundSubstance misuse is associated with cognitive dysfunction. We used a stop signal task to examine deficits in cognitive control in individuals with opioid dependence (OD). We examined how response inhibition and post-error slowing are compromised and whether methadone maintenance treatment (MMT), abstinence duration, and psychiatric comorbidity are related to these measures in individuals with OD.
methodsTwo-hundred-and-sixty-four men with OD who were incarcerated at a detention center and abstinent for up to 2 months (n = 108) or at a correctional facility and abstinent for approximately 6 months (n = 156), 65 OD men under MMT at a psychiatric clinic, and 64 age and education matched healthy control (HC) participants were assessed. We computed the stop signal reaction time (SSRT) to index the capacity of response inhibition and post-error slowing (PES) to represent error-related behavioral adjustment, as in our previous work. We examined group effects with analyses of variance and covariance analyses, followed by planned comparisons. Specifically, we compared OD and HC participants to examine the effects of opioid dependence and MMT and compared OD sub-groups to examine the effects of abstinence duration and psychiatric comorbidity.
resultsThe SSRT was significantly prolonged in OD but not MMT individuals, as compared to HC. The extent of post-error slowing diminished in OD and MMT, as compared to HC (trend; p = 0.061), and there was no difference between the OD and MMT groups. Individuals in longer abstinence were no less impaired in these measures. Furthermore, these results remained when psychiatric comorbidities including misuse of other substances were accounted for.
conclusionsMethadone treatment appears to be associated with relatively intact cognitive control in opioid dependent individuals. MMT may facilitate public health by augmenting cognitive control and thereby mitigating risky behaviors in heroin addicts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.