ArticleMolecules (Basel, Switzerland)2014
The effect of chitin size, shape, source and purification method on immune recognition.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 79 citations in OpenAlex.
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- Black soldier fly (Hermetia illucens) larvae exoskeleton as a potential source of chitin in diets for juvenile channel catfish (Ictalurus punctatus).Fish physiology and biochemistry · 2025Article
- Immunomodulatory natural polysaccharide-based nanoparticles for the treatment of neurodegenerative diseases.Ibrain · 2025Review
- Toll-like receptor 4 (TLR4) is the major pattern recognition receptor triggering the protective effect of amSphere · 2024Article
- Response surface methodology-based optimisation of chitin production and its antioxidant activity fromHeliyon · 2024Article
- Harnessing the Potential of Chitosan and Its Derivatives for Enhanced Functionalities in Food Applications.Foods (Basel, Switzerland) · 2024Review
- Fungal chitin-binding glycoprotein induces Dectin-2-mediated allergic airway inflammation synergistically with chitin.PLoS pathogens · 2024Article
- Rejection of Lepeophtheirus salmonis driven in part by chitin sensing is not impacted by seawater acclimitization in Coho salmon (Oncorhynchus kisutch).Scientific reports · 2023Article
- Dietary supplementation with full-fat Hermetia illucens larvae and multi-probiotics, as a substitute for antibiotics, improves the growth performance, gut health, and antioxidative capacity of weaned pigs.BMC veterinary research · 2023Article
- Article
- Electrosprayed Shrimp and Mushroom Nanochitins on Cellulose Tissue for Skin Contact Application.Molecules (Basel, Switzerland) · 2021Article
- Chitin-rich heteroglycan from Sporothrix schenckii sensu stricto potentiates fungal clearance in a mouse model of sporotrichosis and promotes macrophages phagocytosis.BMC microbiology · 2021Article
- Computational Assessment of Chito-Oligosaccharides Interactions with Plasma Proteins.Marine drugs · 2021Article
- Chitin nanowhiskers from shrimp shell waste as green filler in acrylonitrile-butadiene rubber: Processing and performance properties.Carbohydrate polymers · 2020Article
- Biodegradable Polymeric Micro/Nano-Structures with Intrinsic Antifouling/Antimicrobial Properties: Relevance in Damaged Skin and Other Biomedical Applications.Journal of functional biomaterials · 2020Review
- Synthesis of Biotin-Tagged Chitosan Oligosaccharides and Assessment of Their Immunomodulatory Activity.Frontiers in chemistry · 2020Article
- Can we make Chitosan by Enzymatic Deacetylation of Chitin?Molecules (Basel, Switzerland) · 2019Article
- Natural Polysaccharide Nanomaterials: An Overview of Their Immunological Properties.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The animal immune response to chitin is not well understood and needs to be investigated further. However, this is a challenging topic to study because of the technical difficulties in purifying chitin, and because this material usually comes associated with contaminating components that can activate the immune system. In this study, improvements to previously described purification protocols were investigated for chitin obtained from different sources, including commercial shellfish, Candida albicans yeast and hyphal cell walls, as well as cell walls of the filamentous fungi Aspergillus fumigatus and Mucor circinelloides. The immune response to these different chitin preparations was tested using human peripheral blood mononuclear cells. In agreement with previous literature, small chitin particles of an average size of 0.2 µm were not immunogenic. On the other hand, bigger chitin particles induced in some cases a pro-inflammatory response. The results of this work suggest that not only the purity and size of the chitin particles, but also their shape can influence immune recognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.