ArticleMolecules (Basel, Switzerland)2014
Pharmacological evaluation of total alkaloids from nux vomica: effect of reducing strychnine contents.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 42 citations in OpenAlex.
- Processing-induced detoxification of toxic Traditional Chinese Medicines: a systematic review of attenuation mechanisms at physical, chemical, and in vivo levels.Chinese medicine · 2026Review
- Glycyrrhizic Acid Alleviates Semen Strychni-Induced Neurotoxicity Through the Inhibition of HMGB1 Phosphorylation and Inflammatory Responses.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Effect of a combination ofExperimental and therapeutic medicine · 2023Article
- Pharmacodynamics and acute toxicity studies of Shangke Jiegu tablet with or without cinnabar.Heliyon · 2022Article
- Content Determination and Release Characteristics of Six Components in the Different Phases of "Molecules (Basel, Switzerland) · 2022Article
- The Production and Evaluation of an Electrochemical Sensors for Strychnine and Its Main Metabolite Strychnine N-Oxide for Their Use in Biological Samples.Molecules (Basel, Switzerland) · 2022Article
- Study on the Potential Mechanism ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Nutritional and Physicochemical Characterization ofFoods (Basel, Switzerland) · 2020Article
- Brucine inhibits TNF-α-induced HFLS-RA cell proliferation by activating the JNK signaling pathway.Experimental and therapeutic medicine · 2019Article
- Article
- Rhodium catalyzed diastereoselective synthesis of 2,2,3,3-tetrasubstituted indolines fromChemical science · 2016Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to investigate the possibility of improving the therapeutic efficacy of the total alkaloid fraction (TAF) extracted from processed nux vomica by reducing the strychnine contents. Most strychnine was removed from TAF to obtain the modified total alkaloid fraction (MTAF). The toxicity and pharmacokinetics of TAF and MTAF were further investigated and compared besides their antitumor, analgesic and anti-inflammatory activities. The results showed that the ratios of brucine to strychnine were 1:2.05 and 2.2:1 for TAF and MTAF, respectively, and the toxicity of TAF was about 3.17-fold higher than that of MTAF. Compared to brucine alone, the elimination of brucine was found to be inhibited by other alkaloids in TAF or MTAF except strychnine. Significantly increased pharmacological activities when administered by the oral route were obtained with MTAF in comparison to TAF and nux vomica powder (NVP). In summary, MTAF might replace NVP and TAF in the clinical application of Chinese medicine to obtain much higher efficacy.
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