Evidence map›Paper›PMID 24727245›Full record

ReviewCurrent opinion in neurobiology2014

Signaling regulations of neuronal regenerative ability.

Yi Lu, Stéphane Belin, Zhigang He

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. NeuronaleNeuro · 2026
    Article
  2. Article
  3. The conserved fibroblast growth factor receptor-based signaling is required for dendrite regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. TargetingiScience · 2022
    Article
  17. Article
  18. A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  19. Dysregulation of mTOR Signaling after Brain Ischemia.International journal of molecular sciences · 2022
    Review
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yi LuDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; F.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
Stéphane BelinF.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
Zhigang HeF.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: zhigang.he@childrens.harvard.edu.

Funding

SOCS3 and optic nerve regenerationR01EY021526 · NEI · BOSTON CHILDREN'S HOSPITAL · PI HE, ZHIGANG · 2011 to 2020
$4.1M
New Approach to promote optic nerve regeneration and vision restorationR01EY021342 · NEI · BOSTON CHILDREN'S HOSPITAL · PI HE, ZHIGANG · 2011 to 2014
$1.7M
Signaling Mechanisms mediating effects of Semaphorin3AR01DA015335 · NIDA · CHILDREN'S HOSPITAL BOSTON · PI HE, ZHIGANG · 2001 to 2005
$1.4M
NEI NIH HHS R01 EY021342NEI NIH HHS R01 EY021526NIDA NIH HHS R01 DA015335
6 · The paper itself

Abstract

Different from physiological axon growth during development, a major limiting factor for successful axon regeneration is the poor intrinsic regenerative capacity in mature neurons in the adult mammalian central nervous system (CNS). Recent studies identified several molecular pathways, including PTEN/mTOR, Jak/STAT, DLK/JNK, providing important probes in investigating the mechanisms by which the regenerative ability is regulated. This review will summarize these recent findings and speculate their implications.

Indexed as

AnimalsAxonsCentral Nervous SystemHumansJanus KinasesMAP Kinase Kinase 4Nerve RegenerationNeuronsPTEN PhosphohydrolaseSignal TransductionJanus KinasesMAP Kinase Kinase 4PTEN Phosphohydrolase

Identifiers

PMID24727245
PMCPMC4546824

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.