Evidence map›Paper›PMID 24726987›Full record

ArticleGeneral and comparative endocrinology2014

Establishing regional specificity of neuroestrogen action.

Barney A Schlinger, Luke Remage-Healey, Michelle Rensel

Open access · greenAbstract read
In one paragraph

Article in General and comparative endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
6.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems.Translational research : the journal of laboratory and clinical medicine · 2021
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Barney A SchlingerDept. of Integrative Biology and Physiology and the Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, CA, USA. Electronic address: schlinge@lifesci.ucla.edu.
Luke Remage-HealeyNeuroscience and Behavior Program, Molecular and Cellular Biology Program, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA, USA.
Michelle RenselDept. of Integrative Biology and Physiology and the Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity of Massachusetts Amherst · US

Funding

NEURAL STEROIDOGENIC ENZYMES AND BRAIN FUNCTIONR01MH061994 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCHLINGER, BARNETT ALAN · 2000 to 2014
$4.1M
Modulation of forebrain circuits by local neurosteroid productionR00NS066179 · NINDS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI REMAGE-HEALEY, LUKE R · 2010 to 2012
$721k
NIMH NIH HHS R01 MH061994NINDS NIH HHS R00NS066179Wellcome Trust 061994
6 · The paper itself

Abstract

The specificity of estrogen signaling in brain is defined at one level by the types and distributions of receptor molecules that are activated by estrogens. At another level, as our understanding of the neurobiology of the estrogen synthetic enzyme aromatase has grown, questions have emerged as to how neuroactive estrogens reach specific target receptors in functionally relevant concentrations. Here we explore the spatial specificity of neuroestrogen signaling with a focus on studies of songbirds to provide perspective on some as-yet unresolved questions. Studies conducted in both male and female songbirds have helped to clarify these interesting facets of neuroestrogen physiology.

Indexed as

Organ SpecificityAnimalsAromataseBrainEstradiolEstrogensFemaleMaleMicrodialysisSongbirdsAromataseEstradiolEstrogensAromataseEstradiolNeuroestrogenNeurosteroidSongbird

Identifiers

PMID24726987
PMCPMC4348095
OpenAlexW2007214508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.