ArticleJournal of pain and symptom management2014
An analytical framework for delirium research in palliative care settings: integrated epidemiologic, clinician-researcher, and knowledge user perspectives.
Open access · bronzeAbstract read
In one paragraph
Article in Journal of pain and symptom management, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Barriers to healthcare professionals screening, recognizing, and managing delirium in the adult patients receiving specialist palliative care: a mixed-methods systematic review.BMC palliative care · 2025Pooled it
- The experience of delirium in palliative care settings for patients, family, clinicians and volunteers: A qualitative systematic review and thematic synthesis.Palliative medicine · 2021Pooled it
- The incidence and prevalence of delirium across palliative care settings: A systematic review.Palliative medicine · 2019Pooled it
- Delirium prevention in hospices: Opportunities and limitations - A focused ethnography.Palliative medicine · 2025Article
- Development of a Prediction Model for Delirium in Hospitalized Patients with Advanced Cancer.Cancer research and treatment · 2024Article
- Prevalence of Delirium in End-of-Life Palliative Care Patients: An Observational Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022Observational
- Validity and Reliability of the Memorial Delirium Assessment Scale-Thai Version (MDAS-T) for Assessment of Delirium in Palliative Care Patients.The oncologist · 2020Article
- Use of the brief Confusion Assessment Method in a veteran palliative care population: A pilot validation study.Palliative & supportive care · 2019Observational
- Article
- The experiences of caregivers of patients with delirium, and their role in its management in palliative care settings: an integrative literature review.Psycho-oncology · 2017Review
- Delirium in patients with cancer: assessment, impact, mechanisms and management.Nature reviews. Clinical oncology · 2015Review
- Delirium diagnosis, screening and management.Current opinion in supportive and palliative care · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 10 institutions in 8 countries.
Peter G Lawlor *Division of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Daniel H J Davis *Division of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Mohammed AnsariDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Annmarie HosieDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Salmaan KanjiDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Franco MomoliDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Shirley H BushDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Sharon WatanabeDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
David C CurrowDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Bruno GagnonDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Meera AgarDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Eduardo BrueraDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
David J MeagherDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Sophia E J A de RooijDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Dimitrios AdamisDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Augusto CaraceniDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Katie MarchingtonDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
David J StewartDivision of Palliative Care (P.G.L.), Department of Medicine, Epidemiology and Community Medicine, University of Ottawa; Bruyère Research Institute (P.G.L., S.H.B.), Bruyère Continuing Care; The Ottawa Hospital Research Institute (P.G.L., S.K.), Ottawa, Ontario, Canada; Institute of Public Health (D.H.J.D.), University of Cambridge, Cambridge, United Kingdom; Knowledge Synthesis Group (M.An.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Faculty of Nursing (A.H.), University of Notre Dame, Sydney, New South Wales, Australia; The Ottawa Hospital (S.K.); Clinical Epidemiology Program (F.M.), Ottawa Hospital Research Institute; Children's Hospital of Eastern Ontario Research Institute (F.M.), University of Ottawa; Division of Palliative Care (S.H.B.), Department of Medicine, University of Ottawa, Ottawa, Ontario; Department of Symptom Control and Palliative Care (S.W.), Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; Discipline of Palliative and Supportive Services (D.C.C., M.Ag.), Flinders University, Adelaide, South Australia, Australia; Département de médecine familiale et de médecine d'urgence (B.G.), Université Laval; Centre de recherche du CHU de Québec (B.G.), Québec City, Québec, Canada; South West Sydney Clinical School (M.Ag.), University of New South Wales; Department of Palliative Care (M.Ag.), Braeside Hospital, Hammond Care, Sydney, New South Wales, Australia; The University of Texas M. D. Anderson Cancer Center (E.B.), Houston, Texas, USA; Graduate Entry Medical School (D.J.M.), University of Limerick, Limerick, Ireland; Academic Medical Centre (S.E.J.A.d.R.), University of Amsterdam, Amsterdam, The Netherlands; Research and Academic Institute of Athens (D.A.), Athens, Greece; Palliative Care, Pain Therapy and Rehabilitation Unit (A.C.), Fondazione IRCCS, Istituto Nazionale Dei Tumori, Milan, Italy; Department of Palliative Care (K.M.), Bruyère Continuing Care; and Department of Medical Oncology (D.J.S.), The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Bruyère · CAUniversity of Ottawa · CAOttawa Hospital Research InstituteFlinders University · AUThe University of Notre Dame Australia · AUUniversité Laval · CAUniversity of Amsterdam · NLUniversity of Cambridge · GBUniversity of Limerick · IEUNSW Sydney · AU
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8MParenteral Hydration in Advanced Cancer Patients: A Randomized Controlled TrialR01CA122292 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRUERA, EDUARDO · 2006 to 2009
$2.2MMethylphenidate for Fatigue in Advanced Cancer PatientsR01NR010162 · NINR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRUERA, EDUARDO · 2006 to 2009
$1.3MMorphine versus Methadone as First Line Strong Opioid for Cancer PainR01CA124481 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BRUERA, EDUARDO · 2007 to 2009
$1.2MNCI NIH HHS CA 016672NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA122292NCI NIH HHS R01 CA122292-01NCI NIH HHS R01 CA124481NCI NIH HHS R01 CA124481-01NINR NIH HHS R01 NR010162NINR NIH HHS R01 NR010162-01A1Wellcome Trust 090661
Abstract
contextDelirium often presents difficult management challenges in the context of goals of care in palliative care settings.
objectivesThe aim was to formulate an analytical framework for further research on delirium in palliative care settings, prioritize the associated research questions, discuss the inherent methodological challenges associated with relevant studies, and outline the next steps in a program of delirium research.
methodsWe combined multidisciplinary input from delirium researchers and knowledge users at an international delirium study planning meeting, relevant literature searches, focused input of epidemiologic expertise, and a meeting participant and coauthor survey to formulate a conceptual research framework and prioritize research questions.
resultsOur proposed framework incorporates three main groups of research questions: the first was predominantly epidemiologic, such as delirium occurrence rates, risk factor evaluation, screening, and diagnosis; the second covers pragmatic management questions; and the third relates to the development of predictive models for delirium outcomes. Based on aggregated survey responses to each research question or domain, the combined modal ratings of "very" or "extremely" important confirmed their priority.
conclusionUsing an analytical framework to represent the full clinical care pathway of delirium in palliative care settings, we identified multiple knowledge gaps in relation to the occurrence rates, assessment, management, and outcome prediction of delirium in this population. The knowledge synthesis generated from adequately powered, multicenter studies to answer the framework's research questions will inform decision making and policy development regarding delirium detection and management and thus help to achieve better outcomes for patients in palliative care settings.
Indexed as
DeliriumPalliative CareResearch DesignBiomedical ResearchCritical PathwaysHumansMulticenter Studies as Topicassessmentdecision makingDeliriumhospicepalliative carepredictive modelresearch frameworkrisk factorstreatment
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.