ReviewFrontiers in neuroendocrinology2014
Sex differences in stress-related psychiatric disorders: neurobiological perspectives.
Review in Frontiers in neuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 378 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
378 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Translational interdisciplinary research on human chorionic gonadotropin's enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders.Frontiers in psychiatry · 2025Pooled it
- Validity of chronic restraint stress for modeling anhedonic-like behavior in rodents: a systematic review and meta-analysis.The Journal of international medical research · 2022Pooled it
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- Improvements in stress among Latinas participating in a randomized controlled trial of technology-supported physical activity interventions.Stress and health : journal of the International Society for the Investigation of Stress · 2024Trial
- Effects of stress-related neuromodulators on amygdala and hippocampus resting state functional connectivity.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Prelimbic cortex-associated stress sensitisation and region-specific mitochondrial adaptations across preclinical approaches relevant to PTSD and depression.Neurobiology of stress · 2026Article
- Deiodinase 3 Deficiency Impairs Hippocampal and Lateral Ventricle Neurogenesis in Middle-Aged Female Mice.International journal of molecular sciences · 2026Article
- Epigenetic Control of Stress-Induced Depression: Emerging Roles of HDAC3 and HDAC6.International journal of molecular sciences · 2026Review
- Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications.Frontiers in neuroendocrinology · 2026Review
- Sex Differences in Behavioral Responses to Chronic Unpredictable Mild Stress in Swiss Mice.The European journal of neuroscience · 2026Article
- Associations between adverse childhood experiences and progression to incident psychiatric disorders in older adults: A 22-year cohort study.Translational psychiatry · 2026Article
- Sex Differences in Depression: Adult Cytogenesis as Potential Target for Precision Psychiatry.Cells · 2026Review
- The central amygdala corticotropin releasing factor system regulates anxiety-like behavior in an age- and sex- dependent manner in rats.Addiction neuroscience · 2026Article
- Contextual fear conditioning leads to hypo-innervation of the left ventricular myocardium in female but not male C57BL/6J mice.IBRO neuroscience reports · 2026Article
- Sensitive windows, sensitive outcomes: Early or late-postnatal maternal separation differentially impacts puberty and behavior.Neurobiology of stress · 2026Article
- Science with Seymour Levine: on glucocorticoid action from birth to senescence.Neurobiology of stress · 2026Article
- Psychiatric Risk Implications From Behavioral and Neural Effects of Adolescent Exposure to Environmental Insecticides: A Systematic Review of Rodent Studies.Biological psychiatry · 2026Review
- Sex differences in neural stress responses over psychosocial stress exposure.Brain structure & function · 2026Article
- Investigating the impact of stressful life events on neuroanatomy across adolescence.bioRxiv : the preprint server for biology · 2026Article
318 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Stress is associated with the onset and severity of several psychiatric disorders that occur more frequently in women than men, including posttraumatic stress disorder (PTSD) and depression. Patients with these disorders present with dysregulation of several stress response systems, including the neuroendocrine response to stress, corticolimbic responses to negatively valenced stimuli, and hyperarousal. Thus, sex differences within their underlying circuitry may explain sex biases in disease prevalence. This review describes clinical studies that identify sex differences within the activity of these circuits, as well as preclinical studies that demonstrate cellular and molecular sex differences in stress responses systems. These studies reveal sex differences from the molecular to the systems level that increase endocrine, emotional, and arousal responses to stress in females. Exploring these sex differences is critical because this research can reveal the neurobiological underpinnings of vulnerability to stress-related psychiatric disorders and guide the development of novel pharmacotherapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.