ArticleBMC genomics2014
Patterns of homoeologous gene expression shown by RNA sequencing in hexaploid bread wheat.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 87 citations in OpenAlex.
- Layer-specific genetic variation unlocks secondary metabolite diversity in long-lived clonal peppermint.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Remodeling of homoeolog expression bias buffers stress response in allotetraploid cotton.BMC plant biology · 2026Article
- Genome-wide identification of ethylene receptor protein-coding gene families in wheat and their regulated expression during development and under multiple abiotic stresses.BMC plant biology · 2026Article
- Improving genomic selection in hexaploid wheat with sub-genome additive and epistatic models.G3 (Bethesda, Md.) · 2025Article
- Transcriptomic analysis reveals cloquintocet-mexyl-inducible genes in hexaploid wheat (Triticum aestivum L.).PloS one · 2025Article
- Transgenerational Paternal Inheritance ofInternational journal of molecular sciences · 2023Article
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- Transcriptional gene silencing in bread wheat (Triticum aestivum L.) and its application to regulate male fertility for hybrid seed production.Plant biotechnology journal · 2022Article
- N6-Methyladenosine dynamic changes and differential methylation in wheat grain development.Planta · 2022Article
- Meta-analysis reveals consensus genomic regions associated with multiple disease resistance in wheat (Molecular breeding : new strategies in plant improvement · 2022Article
- Transcriptome Analysis of Developing Wheat Grains at Rapid Expanding Phase Reveals Dynamic Gene Expression Patterns.Biology · 2022Article
- Exploiting the miniature inverted-repeat transposable elements insertion polymorphisms as an efficient DNA marker system for genome analysis and evolutionary studies in wheat and related species.Frontiers in plant science · 2022Article
- Wheat-Frontiers in plant science · 2022Article
- Transcriptomic profiling of wheat near-isogenic lines reveals candidate genes on chromosome 3A for pre-harvest sprouting resistance.BMC plant biology · 2021Article
- Multi-responses of O-methyltransferase genes to salt stress and fiber development of Gossypium species.BMC plant biology · 2021Article
- Article
- Genome-wide analysis of the HSP101/CLPB gene family for heat tolerance in hexaploid wheat.Scientific reports · 2020Article
- Alternative Splicing Diversified the Heat Response and Evolutionary Strategy of ConservedFrontiers in genetics · 2020Article
- Transcriptome analysis of diploid and triploidPeerJ · 2020Article
- Integrative analysis of hexaploid wheat roots identifies signature components during iron starvation.Journal of experimental botany · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundBread wheat (Triticum aestivum) has a large, complex and hexaploid genome consisting of A, B and D homoeologous chromosome sets. Therefore each wheat gene potentially exists as a trio of A, B and D homoeoloci, each of which may contribute differentially to wheat phenotypes. We describe a novel approach combining wheat cytogenetic resources (chromosome substitution 'nullisomic-tetrasomic' lines) with next generation deep sequencing of gene transcripts (RNA-Seq), to directly and accurately identify homoeologue-specific single nucleotide variants and quantify the relative contribution of individual homoeoloci to gene expression.
resultsWe discover, based on a sample comprising ~5-10% of the total wheat gene content, that at least 45% of wheat genes are expressed from all three distinct homoeoloci. Most of these genes show strikingly biased expression patterns in which expression is dominated by a single homoeolocus. The remaining ~55% of wheat genes are expressed from either one or two homoeoloci only, through a combination of extensive transcriptional silencing and homoeolocus loss.
conclusionsWe conclude that wheat is tending towards functional diploidy, through a variety of mechanisms causing single homoeoloci to become the predominant source of gene transcripts. This discovery has profound consequences for wheat breeding and our understanding of wheat evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.