Evidence map›Paper›PMID 24725934›Full record

ArticleVirology2014

Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection.

Alyson A Kelvin, Norbert Degousee, David Banner, Eva Stefanski, Alberto J Leόn, Denis Angoulvant, Stéphane G Paquette, Stephen S H Huang, Ali Danesh, Clinton S Robbins and 6 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Secretory Phospholipase ACell biochemistry and biophysics · 2021
    Review
  5. Article
  6. Article
  7. Lipoquality control by phospholipase AProceedings of the Japan Academy. Series B, Physical and biological sciences · 2017
    Review
  8. Article
  9. The Roles of the Secreted Phospholipase AAdvances in immunology · 2016
    Review
  10. A new era of secreted phospholipase A₂.Journal of lipid research · 2015
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 5 countries.

Alyson A KelvinImmune Diagnostics & Research, Toronto, Ontario, Canada.
Norbert DegouseeDivision of Vascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network and the University of Toronto, Toronto, Ontario, Canada.
David BannerDivision of Experimental Therapeutics, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Eva StefanskiDivision of Vascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network and the University of Toronto, Toronto, Ontario, Canada.
Alberto J LeόnDivision of Experimental Therapeutics, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China.
Denis AngoulvantDivision of Cardiology, Trousseau Hospital, Tours University Hospital Center and EA 4245, Francois Rabelais University, Tours, France.
Stéphane G PaquetteDivision of Experimental Therapeutics, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Stephen S H HuangDivision of Experimental Therapeutics, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Ali DaneshBlood Systems Research Institute, San Francisco, CA 2-Department of Laboratory Medicine, University of California, San Francisco, CA, USA.
Clinton S RobbinsDivision of Experimental Therapeutics, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Hossein NoyanDivision of Experimental Therapeutics, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Mansoor HusainDivision of Experimental Therapeutics, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Heart & Stroke Richard Lewar Centre of Excellence, University of Toronto, University Health Network, Toronto, Ontario, Canada.
Gerard LambeauInstitut de Pharmacologie Moléculaire et Cellulaire, UMR 7275 CNRS and Université de Nice Sophia Antipolis, IPMC, Sophia Antipolis, 06560 Valbonne, France.
Michael GelbDepartments of Chemistry and Biochemistry, University of Washington, Seattle, Washington, USA.
David J KelvinDivision of Experimental Therapeutics, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Immunology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Sezione di Microbiologia Sperimentale e Clinica, Dipartimento di Scienze Biomediche, Universita׳ degli Studi di Sassari, Sassari, Italy. Electronic address: dkelvin@uhnresearch.ca.
Barry B RubinDivision of Vascular Surgery, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network and the University of Toronto, Toronto, Ontario, Canada.
University Health Network · CACentre National de la Recherche Scientifique · FRUniversité de Tours · FRUniversity of California, San Francisco · USUniversity of Washington · US

Funding

Omics-Based Predictive Modeling of Age-Dependent Outcome to Influenza InfectionU01AI111598 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GHEDIN, ELODIE · 2013 to 2017
$13.3M
Biochemical Studies of 14-kDa Phospholipases A2R37HL036235 · NHLBI · UNIVERSITY OF WASHINGTON · PI GELB, MICHAEL H · 2007 to 2016
$4.1M
CIHR MOP126205NHLBI NIH HHS R37 HL036235NHLBI NIH HHS R37HL36235NIAID NIH HHS 1U01AI11598-01NIAID NIH HHS U01 AI111598
6 · The paper itself

Abstract

The role of Group X secreted phospholipase A2 (GX-sPLA2) during influenza infection has not been previously investigated. We examined the role of GX-sPLA2 during H1N1 pandemic influenza infection in a GX-sPLA2 gene targeted mouse (GX(-/-)) model and found that survival after infection was significantly greater in GX(-/-) mice than in GX(+/+) mice. Downstream products of GX-sPLA2 activity, PGD2, PGE2, LTB4, cysteinyl leukotrienes and Lipoxin A4 were significantly lower in GX(-/-) mice BAL fluid. Lung microarray analysis identified an earlier and more robust induction of T and B cell associated genes in GX(-/-) mice. Based on the central role of sPLA2 enzymes as key initiators of inflammatory processes, we propose that activation of GX-sPLA2 during H1N1pdm infection is an early step of pulmonary inflammation and its inhibition increases adaptive immunity and improves survival. Our findings suggest that GX-sPLA2 may be a potential therapeutic target during influenza.

Indexed as

AnimalsB-LymphocytesDisease Models, AnimalGene Expression ProfilingGroup X Phospholipases A2Influenza A Virus, H1N1 SubtypeLungMiceMice, Inbred C57BLMice, KnockoutMicroarray AnalysisOrthomyxoviridae InfectionsSurvival AnalysisT-LymphocytesGroup X Phospholipases A2H1N1 pandemic influenzaHost responseInflammationInfluenzaLeukotrienesLipoxin A(4)PathogenesisPhospholipidsProstaglandinsSecreted phospholipase A(2)

Identifiers

PMID24725934
PMCPMC4106042
OpenAlexW2017573713

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.