Evidence map›Paper›PMID 24725928›Full record

ArticleVirology2014

Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia.

Efrem S Lim, Song Cao, Lori R Holtz, Martin Antonio, O Colin Stine, David Wang

Open access · greenAbstract read
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Efrem S LimDepartments of Molecular Microbiology and Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Song CaoDepartments of Molecular Microbiology and Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Lori R HoltzDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Martin AntonioMedical Research Council Unit, Banjul, The Gambia.
O Colin StineDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
David WangDepartments of Molecular Microbiology and Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: davewang@borcim.wustl.edu.
Washington University in St. Louis · USMRC Unit the Gambia · GMUniversity of Maryland, Baltimore · US

Funding

Virology and Smallpox VaccinationsU54AI057160 · NIAID · WASHINGTON UNIVERSITY · PI OLDSTONE, MICHAEL B · 2003 to 2013
$80.9M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Rodney D Newberry · 2000 to 2026
$30.8M
Washington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8M
Washington University Institute of Clinical and Translational Sciences (KL2)KL2RR024994 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$8.6M
NCATS NIH HHS KL2 TR000450NCATS NIH HHS UL1 TR000448NCRR NIH HHS KL2 RR024994NCRR NIH HHS KL2RR024994NIAID NIH HHS U54 AI057160NIAID NIH HHS U54AI057160NIDDK NIH HHS P30 DK052574
6 · The paper itself

Abstract

We describe the identification of a novel picornavirus recovered from the fecal specimen of a child in The Gambia, provisionally named rosavirus 2. Comparison of the rosavirus 2 complete genome demonstrated 71.9% nucleotide identity to its closest relative rosavirus M-7, an unclassified picornavirus identified from rodent fecal material. A unique RNA structure was predicted in the 3' UTR of rosavirus 2 that was conserved with rosavirus M-7 and cadiciviruses. We detected rosavirus 2 in four pediatric fecal specimens (0.55% prevalence) in a Gambian diarrheal case-control cohort, but we did not detect it in a panel of 634 pediatric diarrheal stool specimens from the USA. There was no statistical evidence that rosavirus 2 was associated with diarrheal cases. This study broadens our understanding of unknown viruses present in children in developing country settings.

Indexed as

Genome, ViralSequence Analysis, DNAAdolescentCase-Control StudiesChildChild, PreschoolCohort StudiesFecesFemaleGambiaHumansInfantMaleMolecular Sequence DataPicornaviridaePicornaviridae InfectionsRNA, ViralDeveloping countryEmerging virusesPicornavirusVirus discovery

Identifiers

PMID24725928
PMCPMC4096378
OpenAlexW2040928448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.