ArticleThe Annals of thoracic surgery2014
Association between preoperative statin use and acute kidney injury biomarkers in cardiac surgical procedures.
Article in The Annals of thoracic surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Pooled it
- Perioperative statin therapy in cardiac surgery: a meta-analysis of randomized controlled trials.Critical care (London, England) · 2016Pooled it
- Evaluation of Short-Term Changes in Serum Creatinine Level as a Meaningful End Point in Randomized Clinical Trials.Journal of the American Society of Nephrology : JASN · 2016Pooled it
- Effect of atorvastatin on the incidence of acute kidney injury following valvular heart surgery: a randomized, placebo-controlled trial.Intensive care medicine · 2016Trial
- Trial
- Preexisting statin therapy is not associated with reduced acute kidney injury following cardiac surgery: a retrospective analysis.Frontiers in pharmacology · 2025Review
- The impact of statin use before intensive care unit admission on patients with acute kidney injury after cardiac surgery.Frontiers in pharmacology · 2023Article
- Long-Term Preoperative Atorvastatin or Rosuvastatin Use in Adult Patients before CABG Does Not Increase Incidence of Postoperative Acute Kidney Injury: A Propensity Score-Matched Analysis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022Article
- Optimal timing of renal replacement therapy for favourable outcome in patients of acute renal failure following cardiac surgery.Indian journal of thoracic and cardiovascular surgery · 2020Article
- Biomarkers of Acute and Chronic Kidney Disease.Annual review of physiology · 2019Review
- Acute kidney injury after cardiac surgery: prevalence, impact and management challenges.International journal of nephrology and renovascular disease · 2019Article
- Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment.Nature reviews. Nephrology · 2017Review
- Statins and acute kidney injury following cardiac surgery: has the last word been told?Journal of thoracic disease · 2016Article
- Application of new acute kidney injury biomarkers in human randomized controlled trials.Kidney international · 2016Article
- Prediction and Prevention of Acute Kidney Injury after Cardiac Surgery.BioMed research international · 2016Review
- Validation of administrative database codes for acute kidney injury in kidney transplant recipients.Canadian journal of kidney health and disease · 2016Article
- Preoperative Statin Use Not Associated With Improved Outcomes After Ascending Aortic Repair.Seminars in thoracic and cardiovascular surgeryArticle
Corrections and comments
- Commented on by
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundAcute kidney injury (AKI) is a serious complication of cardiac operations for which there remains no specific therapy. Animal data and several observational studies suggest that statins prevent AKI, but the results are not conclusive, and many studies are retrospective in nature.
methodsWe conducted a multicenter prospective cohort study of 625 adult patients undergoing elective cardiac operations. All patients were taking statins and were grouped according to whether statins were continued or held in the 24 hours before operation. The primary outcome was AKI as defined by a doubling of serum creatinine or dialysis. The secondary outcome was the peak level of several kidney injury biomarkers. The results were adjusted for demographic and clinical factors.
resultsContinuing (vs holding) a statin before operation was not associated with a lower risk of AKI, as defined by a doubling of serum creatinine or dialysis (adjusted relative risk [RR] 1.09; 95% confidence interval [CI] 0.44, 2.70). However, continuing a statin was associated with a lower risk of elevation of the following AKI biomarkers: urine interleukin-18, urine neutrophil gelatinase-associated lipocalin, urine kidney injury molecule-1, and plasma neutrophil gelatinase-associated lipocalin (adjusted RR 0.34; 95% CI 0.18, 0.62), (adjusted RR 0.41; 95% CI 0.22, 0.76), (adjusted RR 0.37; 95% CI 0.20, 0.76), (adjusted RR 0.62; 95% CI 0.39, 0.98), respectively.
conclusionsStatins may prevent kidney injury after cardiac operations, as evidenced by lower levels of kidney injury biomarkers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.