Evidence map›Paper›PMID 24725582›Full record

Trial reportThe Journal of pediatrics2014

Respiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT).

Timothy P Stevens, Neil N Finer, Waldemar A Carlo, Peter G Szilagyi, Dale L Phelps, Michele C Walsh, Marie G Gantz, Abbot R Laptook, Bradley A Yoder, Roger G Faix and 27 more

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00233324 (Surfactant Positive Airway Pressure and Pulse Oximetry Trial), which is not on this map. Cited by 50 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 4 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00233324 phase3completednot on this map

Surfactant Positive Airway Pressure and Pulse Oximetry Trial (SUPPORT) in Extremely Low Birth Weight Infants

TypeinterventionalSponsorNICHD Neonatal Research NetworkRan2005 to 2016Enrolled1,316ConditionsInfant, Newborn, Diseases, Other Preterm Infants, Infant, Small for Gestational Age, Premature BirthArmsSurfactant, Continuous Positive Airway Pressure (CPAP), Supplemental oxygen with target saturation of 85 to 89%, Supplemental oxygen with target saturation of 91 to 95%
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Pooled it
  2. Thresholds for surfactant use in preterm neonates: a network meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2023
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

37 authors at 20 institutions in 1 country.

Timothy P StevensDepartment of Pediatrics, University of Rochester Medical Center and Golisano Children's Hospital, Rochester, NY. Electronic address: timothy_stevens@urmc.rochester.edu.
Neil N FinerDivision of Neonatology, University of California at San Diego, San Diego, CA.
Waldemar A CarloDivision of Neonatology, University of Alabama at Birmingham, Birmingham, AL.
Peter G SzilagyiDepartment of Pediatrics, University of Rochester Medical Center and Golisano Children's Hospital, Rochester, NY.
Dale L PhelpsDepartment of Pediatrics, University of Rochester Medical Center and Golisano Children's Hospital, Rochester, NY.
Michele C WalshDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH.
Marie G GantzSocial, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, NC.
Abbot R LaptookDepartment of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI.
Bradley A YoderDivision of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT.
Roger G FaixDivision of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT.
Jamie E NewmanSocial, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, NC.
Abhik DasSocial, Statistical, and Environmental Sciences, RTI International, Rockville, MD.
Barbara T DoSocial, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, NC.
Kurt SchiblerDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
Wade RichDivision of Neonatology, University of California at San Diego, San Diego, CA.
Nancy S NewmanDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH.
Richard A EhrenkranzDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT.
Myriam Peralta-CarcelenDivision of Neonatology, University of Alabama at Birmingham, Birmingham, AL.
Betty R VohrDepartment of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI.
Deanne E Wilson-CostelloDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH.
Kimberly YoltonDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
Roy J HeyneDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Patricia W EvansDepartment of Pediatrics, University of Texas Medical School at Houston, Houston, TX.
Yvonne E VaucherDivision of Neonatology, University of California at San Diego, San Diego, CA.
Ira Adams-ChapmanDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA.
Elisabeth C McGowanDivision of Newborn Medicine, Department of Pediatrics, Floating Hospital for Children, Tufts Medical Center, Boston, MA.
Anna BodnarDivision of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT.
Athina PappasDepartment of Pediatrics, Wayne State University, Detroit, MI.
Susan R HintzDivision of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA.
Michael J AcarreguiDepartment of Pediatrics, University of Iowa, Iowa City, IA.
Janell FullerDivision of Neonatology, University of New Mexico Health Sciences Center, Albuquerque, NM.
Ricki F GoldsteinDepartment of Pediatrics, Duke University, Durham, NC.
Charles R BauerUniversity of Miami Miller School of Medicine, Miami, FL.
T Michael O'SheaDivision of Neonatology, Wake Forest University School of Medicine, Winston-Salem, NC.
Gary J MyersDepartment of Pediatrics, University of Rochester Medical Center and Golisano Children's Hospital, Rochester, NY.
Rosemary D HigginsEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
RTI International · USCase Western Reserve University · USUniversity of California, San Diego · USUniversity of Utah · USGolisano Children's Hospital · USUniversity of Alabama at Birmingham · USUniversity of Rochester · USBrown University · USCincinnati Children's Hospital Medical Center · USDuke University · USEmory University · USLucile Packard Children's Hospital · USNational Institutes of Health · USThe University of Texas Health Science Center at Houston · USThe University of Texas Southwestern Medical Center · USTufts Children's Hospital · USUniversity of Cincinnati · USUniversity of Iowa · USUniversity of Miami · USUniversity of New Mexico · US

Funding

Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
WORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUNDLEY, WILLIAM GREGORY · 1992 to 2010
$35.2M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
UNIVERSITY OF IOWA CTSA FOR PEDIATRIC RESEARCHUL1RR024979 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$31.8M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1RR025744 · NCRR · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2008 to 2011
$22.4M
VITAMIN K DEFICIENCY IN CHOLESTATIC LIVER DISEASEM01RR008084 · NCRR · CINCINNATI CHILDRENS HOSP MED CTR · PI HEUBI, JAMES E. · 1994 to 2009
$20.6M
The University of Rochester's Clinical and Translational Science InstituteUL1TR000042 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$14.4M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021385 · NICHD · WAYNE STATE UNIVERSITY · PI SHANKARAN, SEETHA · 1991 to 2015
$8.7M
NCATS NIH HHS UL1 TR000042NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001085NCRR NIH HHS M01 RR125NCRR NIH HHS M01 RR16587NCRR NIH HHS M01 RR30NCRR NIH HHS M01 RR32NCRR NIH HHS M01 RR39NCRR NIH HHS M01 RR44NCRR NIH HHS M01 RR54NCRR NIH HHS M01 RR59NCRR NIH HHS M01 RR633NCRR NIH HHS M01 RR64NCRR NIH HHS M01 RR70NCRR NIH HHS M01 RR7122NCRR NIH HHS M01 RR750NCRR NIH HHS M01 RR80NCRR NIH HHS M01 RR8084NCRR NIH HHS M01 RR997NCRR NIH HHS RR25008NCRR NIH HHS UL1 RR024139NCRR NIH HHS UL1 RR024979NCRR NIH HHS UL1 RR025744NCRR NIH HHS UL1 RR24139NCRR NIH HHS UL1 RR24979NCRR NIH HHS UL1 RR25744NICHD NIH HHS K23 HD050646NICHD NIH HHS K23 HD50646NICHD NIH HHS U10 HD021364NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD021397NICHD NIH HHS U10 HD027851NICHD NIH HHS U10 HD027853NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD027880NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD034216NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD040461NICHD NIH HHS U10 HD040492NICHD NIH HHS U10 HD040498NICHD NIH HHS U10 HD040521NICHD NIH HHS U10 HD040689NICHD NIH HHS U10 HD053109NICHD NIH HHS U10 HD053119NICHD NIH HHS U10 HD053124NICHD NIH HHS U10 HD21364NICHD NIH HHS U10 HD21373NICHD NIH HHS U10 HD21385NICHD NIH HHS U10 HD21397NICHD NIH HHS U10 HD27851NICHD NIH HHS U10 HD27853NICHD NIH HHS U10 HD27856NICHD NIH HHS U10 HD27871NICHD NIH HHS U10 HD27880NICHD NIH HHS U10 HD27904NICHD NIH HHS U10 HD34216NICHD NIH HHS U10 HD36790NICHD NIH HHS U10 HD40461NICHD NIH HHS U10 HD40492NICHD NIH HHS U10 HD40498NICHD NIH HHS U10 HD40521NICHD NIH HHS U10 HD40689NICHD NIH HHS U10 HD53089NICHD NIH HHS U10 HD53109NICHD NIH HHS U10 HD53119NICHD NIH HHS U10 HD53124NICHD NIH HHS UG1 HD027851NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD068278NICHD NIH HHS UG1 HD087229
6 · The paper itself

Abstract

objectiveTo explore the early childhood pulmonary outcomes of infants who participated in the National Institute of Child Health and Human Development's Surfactant Positive Airway Pressure and Pulse Oximetry Randomized Trial (SUPPORT), using a factorial design that randomized extremely preterm infants to lower vs higher oxygen saturation targets and delivery room continuous positive airway pressure (CPAP) vs intubation/surfactant. STUDY

designThe Breathing Outcomes Study, a prospective secondary study to the Surfactant Positive Airway Pressure and Pulse Oximetry Randomized Trial, assessed respiratory morbidity at 6-month intervals from hospital discharge to 18-22 months corrected age (CA). Two prespecified primary outcomes-wheezing more than twice per week during the worst 2-week period and cough longer than 3 days without a cold-were compared for each randomized intervention.

resultsOne or more interviews were completed for 918 of the 922 eligible infants. The incidences of wheezing and cough were 47.9% and 31.0%, respectively, and did not differ between the study arms of either randomized intervention. Infants randomized to lower vs higher oxygen saturation targets had a similar risk of death or respiratory morbidity (except for croup and treatment with oxygen or diuretics at home). Infants randomized to CPAP vs intubation/surfactant had fewer episodes of wheezing without a cold (28.9% vs 36.5%; P<.05), respiratory illnesses diagnosed by a doctor (47.7% vs 55.2%; P<.05), and physician or emergency room visits for breathing problems (68.0% vs 72.9%; P<.05) by 18-22 months CA.

conclusionTreatment with early CPAP rather than intubation/surfactant is associated with less respiratory morbidity by 18-22 months CA. Longitudinal assessment of pulmonary morbidity is necessary to fully evaluate the potential benefits of respiratory interventions for neonates.

Indexed as

Continuous Positive Airway PressureDelivery RoomsFemaleHumansInfantInfant, Extremely PrematureInfant, NewbornInfant, PrematureMaleOximetryOxygenProspective StudiesPulmonary SurfactantsRespiratory Distress Syndrome, NewbornSurveys and QuestionnairesTreatment OutcomeOxygenPulmonary Surfactants

Identifiers

PMID24725582
PMCPMC4111960
OpenAlexW2053931185

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.