Evidence map›Paper›PMID 24725484›Full record

ReviewThe Urologic clinics of North America2014

What do the screening trials really tell us and where do we go from here?

Ruth D Etzioni, Ian M Thompson

Abstract readReview
In one paragraph

Review in The Urologic clinics of North America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Prostate Cancer Screening.The Medical clinics of North America · 2018
    Review
  4. Review
  5. Article
  6. Clonal evaluation of prostate cancer foci in biopsies with discontinuous tumor involvement by dual ERG/SPINK1 immunohistochemistry.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ruth D EtzioniDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M2-B230, PO Box 19024, Seattle, WA 98109-1024, USA. Electronic address: retzioni@fhcrc.org.
Ian M ThompsonThe Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, MC-7845, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
SAN ANTONIO CENTER OF BIOMARKERS OF RISK FOR PROSTATE CAU01CA086402 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LEACH, ROBIN JEAN, THOMPSON, IAN M. · 2000 to 2018
$33.1M
Modeling prostate cancer control: prevention, screening, treatment, followup careU01CA157224 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DE KONING, HARRY J, ETZIONI, RUTH D · 2010 to 2014
$5.3M
NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA015704-36NCI NIH HHS P30 CA054174NCI NIH HHS U01 CA086402NCI NIH HHS U01 CA157224NCI NIH HHS U01 CA86402
6 · The paper itself

Abstract

Publication of apparently conflicting results from 2 large trials of prostate cancer screening has intensified the debate about prostate-specific antigen (PSA) testing and has led to a recommendation against screening from the US Preventive Services Task Force. This article reviews the trials and discusses the limitations of their empirical results in informing public health policy. In particular, the authors explain why harm-benefit trade-offs based on empirical results may not accurately reflect the trade-offs expected under long-term population screening. This information should be useful to clinicians in understanding the implications of these studies regarding the value of PSA screening.

Indexed as

Clinical Trials as TopicEarly Detection of CancerHumansMaleMass ScreeningProstate-Specific AntigenProstatic NeoplasmsProstate-Specific AntigenClinical trialsMass screeningProstate cancerProstate-specific antigenPublic health policySimulation modeling

Identifiers

PMID24725484
PMCPMC4380283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.