Evidence map›Paper›PMID 24725369›Full record

Trial reportBMC pulmonary medicine2014

Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial.

Timm Greulich, Christoph Nell, Janine Koepke, Juliane Fechtel, Maja Franke, Bernd Schmeck, Daniel Haid, Sandra Apelt, Silke Filipovic, Klaus Kenn and 3 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pulmonary medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 8 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 8 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Design of pulmonary rehabilitation programmes during acute exacerbations of COPD: a systematic review and network meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2020
    Pooled it
  5. The effect of whole body vibration on health-related quality of life in patients with chronic conditions: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. QUALITY OF LIFE OF PATIENTS WITH METABOLIC SYNDROME IS IMPROVED AFTER WHOLE BODY VIBRATION EXERCISES.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017
    Trial
  12. Article
  13. Article
  14. Article
  15. Content, uptake and adherence of exercise interventions after an acute exacerbation of COPD: a scoping review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Timm Greulich
Christoph Nell
Janine Koepke
Juliane Fechtel
Maja Franke
Bernd Schmeck
Daniel Haid
Sandra Apelt
Silke Filipovic
Klaus Kenn
Sabina Janciauskiene
Claus Vogelmeier
Andreas Rembert KoczullaDepartment of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University, Member of the German Center for Lung Research (DZL), Marburg 35043, Germany. koczulla@med.uni-marburg.de.
German Center for Lung Research · DEMedizinische Hochschule Hannover · DESchön Klinik Berchtesgadener Land · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with stable COPD show improvements in exercise capacity and muscular function after the application of whole body vibration. We aimed to evaluate whether this modality added to conventional physiotherapy in exacerbated hospitalised COPD patients would be safe and would improve exercise capacity and quality of life.

methods49 hospitalised exacerbated COPD patients were randomized (1:1) to undergo physiotherapy alone or physiotherapy with the addition of whole body vibration. The primary endpoint was the between-group difference of the 6-minute walking test (day of discharge - day of admission). Secondary assessments included chair rising test, quality of life, and serum marker analysis.

resultsWhole body vibration did not cause procedure-related adverse events. Compared to physiotherapy alone, it led to significantly stronger improvements in 6-minute walking test (95.55 ± 76.29 m vs. 6.13 ± 81.65 m; p = 0.007) and St. Georges Respiratory Questionnaire (-6.43 ± 14.25 vs. 5.59 ± 19.15, p = 0.049). Whole body vibration increased the expression of the transcription factor peroxisome proliferator receptor gamma coactivator-1-α and serum levels of irisin, while it decreased serum interleukin-8.

conclusionWhole body vibration during hospitalised exacerbations did not cause procedure-related adverse events and induced clinically significant benefits regarding exercise capacity and health-related quality of life that were associated with increased serum levels of irisin, a marker of muscle activity.

trial registrationGerman Clinical Trials Register DRKS00005979. Registered 17 March 2014.

Indexed as

Physical Therapy ModalitiesAgedDisease ProgressionExercise ToleranceFemaleFibronectinsHospitalizationHumansMalePulmonary Disease, Chronic ObstructiveQuality of LifeSingle-Blind MethodVibrationFibronectinsFNDC5 protein, human

Identifiers

PMID24725369
PMCPMC4021435
OpenAlexW2012086801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.