ArticleBipolar disorders2014
Bipolar polygenic loading and bipolar spectrum features in major depressive disorder.
Article in Bipolar disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth.Translational psychiatry · 2023Article
- Pediatric Bipolar Disorder: Evolution in Clinical and Biological Markers and Future Perspectives.Current neuropharmacology · 2023Article
- Studying individual risk factors for self-harm in the UK Biobank: A polygenic scoring and Mendelian randomisation study.PLoS medicine · 2020Article
- Polygenic risk score: use in migraine research.The journal of headache and pain · 2018Review
- Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations.NeuroImage. Clinical · 2017Article
- Molecular circadian rhythm shift due to bright light exposure before bedtime is related to subthreshold bipolarity.Scientific reports · 2016Article
- Polygenic Scores in Epidemiology: Risk Prediction, Etiology, and Clinical Utility.Current epidemiology reports · 2015Article
- Childhood IQ and risk of bipolar disorder in adulthood: prospective birth cohort study.BJPsych open · 2015Article
- Integrated neurobiology of bipolar disorder.Frontiers in psychiatry · 2014Review
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11 authors.
Funding
Abstract
objectivesFamily and genetic studies indicate overlapping liability for major depressive disorder and bipolar disorder. The purpose of the present study was to determine whether this shared genetic liability influences clinical presentation.
methodsA polygenic risk score for bipolar disorder, derived from a large genome-wide association meta-analysis, was generated for each subject of European-American ancestry (n = 1,274) in the Sequential Treatment Alternatives to Relieve Depression study (STAR*D) outpatient major depressive disorder cohort. A hypothesis-driven approach was used to test for association between bipolar disorder risk score and features of depression associated with bipolar disorder in the literature. Follow-up analyses were performed in two additional cohorts.
resultsA generalized linear mixed model including seven features hypothesized to be associated with bipolar spectrum illness was significantly associated with bipolar polygenic risk score [F = 2.07, degrees of freedom (df) = 7, p = 0.04]. Features included early onset, suicide attempt, recurrent depression, atypical depression, subclinical mania, subclinical psychosis, and severity. Post-hoc univariate analyses demonstrated that the major contributors to this omnibus association were onset of illness at age ≤ 18 years [odds ratio (OR) = 1.2, p = 0.003], history of suicide attempt (OR = 1.21, p = 0.03), and presence of at least one manic symptom (OR = 1.16, p = 0.02). The maximal variance in these traits explained by polygenic score ranged from 0.8% to 1.1%. However, analyses in two replication cohorts testing a five-feature model did not support this association.
conclusionsBipolar genetic loading appeared to be associated with bipolar-like presentation in major depressive disorder in the primary analysis. However, the results were at most inconclusive because of lack of replication. Replication efforts were challenged by different ascertainment and assessment strategies in the different cohorts. The methodological approach described here may prove useful in applying genetic data to clarify psychiatric nosology in future studies.
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