SynthesisAllergy2014
Job strain and the risk of severe asthma exacerbations: a meta-analysis of individual-participant data from 100 000 European men and women.
Synthesis in Allergy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Genetic and environmental risk factors of asthma: a narrative review.Frontiers in immunology · 2026Pooled it
- Pooled it
- The multiple roles of life stress in metabolic disorders.Nature reviews. Endocrinology · 2023Review
- Exposure to Violence, Psychosocial Stress, and Asthma.American journal of respiratory and critical care medicine · 2020Review
- Multicohort study of change in job strain, poor mental health and incident cardiometabolic disease.Occupational and environmental medicine · 2019Article
- Prospective associations of psychosocial work exposures with mortality in France: STRESSJEM study protocol.BMJ open · 2019Article
- Work-related stress and incident asthma and rhinitis: results from the SOLAR study.International archives of occupational and environmental health · 2019Article
- Job strain and loss of healthy life years between ages 50 and 75 by sex and occupational position: analyses of 64 934 individuals from four prospective cohort studies.Occupational and environmental medicine · 2018Article
- Effects of stress on the development and progression of cardiovascular disease.Nature reviews. Cardiology · 2018Review
- The longitudinal relationship of work stress with peak expiratory flow: a cohort study.International archives of occupational and environmental health · 2017Article
- Change in βJournal of psychosomatic research · 2017Article
- Work stress, family stress and asthma: a cross-sectional study among women in China.International archives of occupational and environmental health · 2017Article
- Work Stress as a Risk Factor for Cardiovascular Disease.Current cardiology reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 18 institutions in 6 countries.
Funding
Abstract
backgroundMany patients and healthcare professionals believe that work-related psychosocial stress, such as job strain, can make asthma worse, but this is not corroborated by empirical evidence. We investigated the associations between job strain and the incidence of severe asthma exacerbations in working-age European men and women.
methodsWe analysed individual-level data, collected between 1985 and 2010, from 102 175 working-age men and women in 11 prospective European studies. Job strain (a combination of high demands and low control at work) was self-reported at baseline. Incident severe asthma exacerbations were ascertained from national hospitalization and death registries. Associations between job strain and asthma exacerbations were modelled using Cox regression and the study-specific findings combined using random-effects meta-analyses.
resultsDuring a median follow-up of 10 years, 1 109 individuals experienced a severe asthma exacerbation (430 with asthma as the primary diagnostic code). In the age- and sex-adjusted analyses, job strain was associated with an increased risk of severe asthma exacerbations defined using the primary diagnostic code (hazard ratio, HR: 1.27, 95% confidence interval, CI: 1.00, 1.61). This association attenuated towards the null after adjustment for potential confounders (HR: 1.22, 95% CI: 0.96, 1.55). No association was observed in the analyses with asthma defined using any diagnostic code (HR: 1.01, 95% CI: 0.86, 1.19).
conclusionsOur findings suggest that job strain is probably not an important risk factor for severe asthma exacerbations leading to hospitalization or death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.