ArticleBipolar disorders2014
Association of obesity and treated hypertension and diabetes with cognitive ability in bipolar disorder and schizophrenia.
Article in Bipolar disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 82 citations in OpenAlex.
- Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin.Journal of psychiatric research · 2021Trial
- Efficacy and safety of cariprazine in bipolar I depression: A double-blind, placebo-controlled phase 3 study.Bipolar disorders · 2020Trial
- The role of metabolic health in neurostructural and cognitive alterations in bipolar disorders.Psychological medicine · 2026Article
- Demographic and Clinical Correlates of Body Mass Index in Older Age Bipolar Disorder: Results from the GAGE-BD Project.Medicina (Kaunas, Lithuania) · 2026Article
- Association Between Metabolic Syndrome, Obesity, and Cognitive Performances in Individuals With Bipolar Disorders: Cross-Sectional and Longitudinal Analyses in the FACE-BD Cohort.Acta psychiatrica Scandinavica · 2026Article
- Sex differences in the association of overweight with cognitive performance in individuals with first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2024Article
- Association of obesity to reaction time and visual memory in schizophrenia.Schizophrenia research. Cognition · 2024Article
- Turkish Adaptation of the Health Improvement Profile for the Evaluation of Physical Well-Being of Individuals With Severe Mental Illness.Florence Nightingale journal of nursing · 2024Article
- The Bidirectional Relationship between Weight Gain and Cognitive Function in First-Episode Schizophrenia: A Longitudinal Study in China.Brain sciences · 2024Article
- Depressive disorder, bipolar disorder, and associated factors among adults, in the Eastern part of Ethiopia.BMC psychiatry · 2024Article
- Association between increased BMI and cognitive function in first-episode drug-naïve male schizophrenia.Frontiers in psychiatry · 2024Article
- Association of clinical symptoms and cardiometabolic dysregulations in patients with schizophrenia spectrum disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Association Between Metabolic Risk Factors and Cognitive Impairment in Schizophrenia Based on Sex.Psychiatry investigation · 2023Article
- Interactive relationships of Type 2 diabetes and bipolar disorder with cognition: evidence of putative premature cognitive ageing in the UK Biobank Cohort.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Nutrition, Overweight, and Cognition in Euthymic Bipolar Individuals Compared to Healthy Controls.Nutrients · 2022Article
- Comorbidity Patterns of Mood Disorders in Adult Inpatients: Applying Association Rule Mining.Healthcare (Basel, Switzerland) · 2021Article
- APOE E4 is associated with hyperlipidemia and obesity in elderly schizophrenic patients.Scientific reports · 2021Article
- Cognitive ability and metabolic physical health in first-episode psychosis.Schizophrenia research. Cognition · 2021Article
- Correlations between age, biomedical variables, and cognition in patients with schizophrenia.Schizophrenia research. Cognition · 2020Article
- Call to action regarding the vascular-bipolar link: A report from the Vascular Task Force of the International Society for Bipolar Disorders.Bipolar disorders · 2020Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
objectivesPeople with bipolar disorder or schizophrenia are at greater risk for obesity and other cardio-metabolic risk factors, and several prior studies have linked these risk factors to poorer cognitive ability. In a large ethnically homogenous outpatient sample, we examined associations among variables related to obesity, treated hypertension and/or diabetes and cognitive abilities in these two patient populations.
methodsIn a study cohort of outpatients with either bipolar disorder (n = 341) or schizophrenia (n = 417), we investigated the association of self-reported body mass index and current use of medications for hypertension or diabetes with performance on a comprehensive neurocognitive battery. We examined sociodemographic and clinical factors as potential covariates.
resultsPatients with bipolar disorder were less likely to be overweight or obese than patients with schizophrenia, and also less likely to be prescribed medication for hypertension or diabetes. However, obesity and treated hypertension were associated with worse global cognitive ability in bipolar disorder (as well as with poorer performance on individual tests of processing speed, reasoning/problem-solving, and sustained attention), with no such relationships observed in schizophrenia. Obesity was not associated with symptom severity in either group.
conclusionsAlthough less prevalent in bipolar disorder compared to schizophrenia, obesity was associated with substantially worse cognitive performance in bipolar disorder. This association was independent of symptom severity and not present in schizophrenia. Better understanding of the mechanisms and management of obesity may aid in efforts to preserve cognitive health in bipolar disorder.
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