ReviewBritish journal of clinical pharmacology2014
Understanding genetic variation - the value of systems biology.
Review in British journal of clinical pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Cocoa bean fingerprinting via correlation networks.NPJ science of food · 2022Article
- Two classes of functional connectivity in dynamical processes in networks.Journal of the Royal Society, Interface · 2021Article
- A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity.Communications biology · 2021Article
- Chromosomal origin of replication coordinates logically distinct types of bacterial genetic regulation.NPJ systems biology and applications · 2020Article
- The E. coli transcriptional regulatory network and its spatial embedding.The European physical journal. E, Soft matter · 2019Article
- Connectivity and complex systems: learning from a multi-disciplinary perspective.Applied network science · 2018Review
- The interdependent network of gene regulation and metabolism is robust where it needs to be.Nature communications · 2017Article
- Distinct metabolic network states manifest in the gene expression profiles of pediatric inflammatory bowel disease patients and controls.Scientific reports · 2016Article
- Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases.Briefings in bioinformatics · 2016Article
- Parsing interindividual drug variability: an emerging role for systems pharmacology.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmacology is currently transformed by the vast amounts of genome-associated information available for system-level interpretation. Here I review the potential of systems biology to facilitate this interpretation, thus paving the way for the emerging field of systems pharmacology. In particular, I will show how gene regulatory and metabolic networks can serve as a framework for interpreting high throughput data and as an interface to detailed dynamical models. In addition to the established connectivity analyses of effective networks, I suggest here to also analyze higher order architectural properties of effective networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.