ArticleThe American journal on addictions
Relationships of behavioral measures of frontal lobe dysfunction with underlying electrophysiology in cocaine-dependent patients.
Article in The American journal on addictions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Transcranial magnetic stimulation in cocaine use disorder and the risk of seizure: a review of the evidence.Frontiers in psychiatry · 2026Review
- Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine AFrontiers in pharmacology · 2018Article
- Prefrontal gray matter volume recovery in treatment-seeking cocaine-addicted individuals: a longitudinal study.Addiction biology · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
BACKGROUND AND
objectivesDespite evidence that frontal lobe functioning is impaired in cocaine-dependent individuals, relationships between behavioral measures of frontal dysfunction and electrophysiological measures of inhibition in cocaine use have not been explored.
methodsUsing the Frontal Systems Behavior Scale (FrSBe), frontal dysfunction was assessed in a group of abstinent cocaine-dependent subjects (N = 49) and healthy controls (N = 32). Using transcranial magnetic stimulation (TMS) and evoked potential (EP)-based electrophysiological measures of inhibition, we assessed associations between these measures and FrSBe estimates of frontal dysfunction.
resultsPatients had significantly higher FrSBe scores for executive dysfunction, disinhibition, and apathy than controls. Lower TMS-based resting motor thresholds (ie, hyperexcitability) were significantly associated with higher executive dysfunction scores in the patients. CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: Relationships between FrSBe scores and TMS-based measures highlight neurophysiological aberrations underlying frontal lobe dysfunction in cocaine abusers. TMS and EP measures may be useful probes of the intermediary steps between frontal lobe dysfunction and addictive behavior.
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