ArticleACS nano2014
Engineering cellular response using nanopatterned bulk metallic glass.
Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 98 citations in OpenAlex.
- Dental implant nanotopography for peri-implant tissue stability: soft-tissue sealing, innate immune calibration, and active biointerface regulation.International journal of implant dentistry · 2026Review
- Hierarchical Surface Pattern on Ni-Free Ti-Based Bulk Metallic Glass to Control Cell Interactions.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Erythrocyte-Inspired Functional Materials for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Controllable graphene oxide-based biocompatible hybrid interface as an anti-fibrotic coating for metallic implants.Materials today. Bio · 2022Article
- Immunomodulation Strategies for the Successful Regeneration of a Tissue-Engineered Vascular Graft.Advanced healthcare materials · 2022Review
- Cellular nanointerface of vertical nanostructure arrays and its applications.Nanoscale advances · 2022Review
- Integration of Biofunctional Molecules into 3D-Printed Polymeric Micro-/Nanostructures.Polymers · 2022Article
- Engineering Nanopatterned Structures to Orchestrate Macrophage Phenotype by Cell Shape.Journal of functional biomaterials · 2022Article
- Mitigating challenges and expanding the future of vascular tissue engineering-are we there yet?Frontiers in physiology · 2022Article
- Unleashing nanofabrication through thermomechanical nanomolding.Science advances · 2021Article
- Tutorial: using nanoneedles for intracellular delivery.Nature protocols · 2021Review
- Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction.Cells · 2021Review
- Biocompatibility of nanomaterials and their immunological properties.Biomedical materials (Bristol, England) · 2021Review
- Emerging Roles of 1D Vertical Nanostructures in Orchestrating Immune Cell Functions.Advanced materials (Deerfield Beach, Fla.) · 2020Review
- Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications.Journal of nanobiotechnology · 2020Review
- Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis.Advanced healthcare materials · 2019Review
- Physical activation of innate immunity by spiky particles.Nature nanotechnology · 2018Article
- Nanopatterned bulk metallic glass-based biomaterials modulate macrophage polarization.Acta biomaterialia · 2018Article
- Regulation of Mesenchymal Stem Cell Differentiation by Nanopatterning of Bulk Metallic Glass.Scientific reports · 2018Article
- Peptide-based coatings for flexible implantable neural interfaces.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Nanopatterning of biomaterials is rapidly emerging as a tool to engineer cell function. Bulk metallic glasses (BMGs), a class of biocompatible materials, are uniquely suited to study nanopattern-cell interactions as they allow for versatile fabrication of nanopatterns through thermoplastic forming. Work presented here employs nanopatterned BMG substrates to explore detection of nanopattern feature sizes by various cell types, including cells that are associated with foreign body response, pathology, and tissue repair. Fibroblasts decreased in cell area as the nanopattern feature size increased, and fibroblasts could detect nanopatterns as small as 55 nm in size. Macrophages failed to detect nanopatterns of 150 nm or smaller in size, but responded to a feature size of 200 nm, resulting in larger and more elongated cell morphology. Endothelial cells responded to nanopatterns of 100 nm or larger in size by a significant decrease in cell size and elongation. On the basis of these observations, nondimensional analysis was employed to correlate cellular morphology and substrate nanotopography. Analysis of the molecular pathways that induce cytoskeletal remodeling, in conjunction with quantifying cell traction forces with nanoscale precision using a unique FIB-SEM technique, enabled the characterization of underlying biomechanical cues. Nanopatterns altered serum protein adsorption and effective substrate stiffness, leading to changes in focal adhesion density and compromised activation of Rho-A GTPase in fibroblasts. As a consequence, cells displayed restricted cell spreading and decreased collagen production. These observations suggest that topography on the nanoscale can be designed to engineer cellular responses to biomaterials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.