ArticleArchives of Iranian medicine2014
Endoscopic screening for precancerous lesions of the esophagus in a high risk area in Northern Iran.
Article in Archives of Iranian medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02311712 (Non-endoscopic Esophageal Cancer Screening Program in Northern Iran), which is not on this map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-endoscopic Esophageal Cancer Screening Program in Northern Iran
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran.British journal of cancer · 2014Trial
- Is random biopsy necessary for normal esophageal mucosa during chromoendoscopy? Evidence from a population-based cohort study.BMC medicine · 2026Article
- Outcomes of upper gastrointestinal cancer screening in high-risk individuals: a population-based prospective study in Northeast China.BMJ open · 2022Article
- Investigations concerning the impact of consumption of hot beverages on acute cytotoxic and genotoxic effects in oral mucosa cells.Scientific reports · 2021Article
- Article
- Esophageal Histological Precursor Lesions and Subsequent 8.5-Year Cancer Risk in a Population-Based Prospective Study in China.The American journal of gastroenterology · 2020Article
- Determinants of participation and detection rate of upper gastrointestinal cancer from population-based screening program in China.Cancer medicine · 2019Article
- Association between coffee or tea drinking and Barrett's esophagus or esophagitis: an Italian study.European journal of clinical nutrition · 2017Article
- Predicting malignant transformation of esophageal squamous cell lesions by combined biomarkers in an endoscopic screening program.World journal of gastroenterology · 2016Article
- The Discovery and Validation of Biomarkers for the Diagnosis of Esophageal Squamous Dysplasia and Squamous Cell Carcinoma.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- Esophageal Squamous Dysplasia is Common in Asymptomatic Kenyans: A Prospective, Community-Based, Cross-Sectional Study.The American journal of gastroenterology · 2016Article
- Simultaneous Esophageal Squamous Cell Carcinoma and Adenocarcinoma: A Case Report.Middle East journal of digestive diseases · 2015Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundEsophageal squamous cell carcinoma (ESCC) is a major health problem in many developing countries including Iran. ESCC has a very poor prognosis, largely due to late diagnosis. As a first step in developing an early detection and treatment program, we conducted a population-based endoscopic screening for ESCC and its precursor lesion, esophageal squamous dysplasia (ESD) in asymptomatic adults from Golestan Province, northern Iran, a high-risk area for ESCC, to evaluate the feasibility of such a program and to document the prevalence and risk factor correlates of ESD.
methodsThis cross-sectional study was conducted among participants of the Golestan Cohort Study (GCS), a population-based cohort of 50,000 adults in eastern Golestan Province. Randomly selected GCS participants were invited by telephone. Those who accepted were referred to a central endoscopy clinic. Eligible subjects were consented and then asked to fill in a brief questionnaire. Detailed information about selected risk factors was obtained from the GCS main database. Endoscopic examination with Lugol's iodine staining was performed, biopsies were taken from unstained lesions as well as the normally stained mucosa of the esophagus, and the biopsies were diagnosed by expert pathologists according to previously described criteria.
resultsIn total, 1906 GCS subjects were invited, of whom only 302 subjects (15.8%) were successfully enrolled. Esophagitis (29.5%) and ESD (6.0%) were the most common pathological diagnoses. Turkmen ethnicity (adjusted OR = 8.61; 95%CI: 2.48-29.83), being older than the median age (OR = 7.7; 95% CI: 1.99-29.87), and using deep frying cooking methods (OR = 4.65; 95%CI: 1.19-18.22) were the strongest predictors for ESD. There were significant relationships between esophagitis and smoking (p-value<0.001), drinking hot tea (P value = 0.02) and lack of education (P value = 0.004).
conclusionWe observed a low rate for participation in endoscopic screening. Overall prevalence of ESD was 6.0%. Developing non-endoscopic primary screening methods and screening individuals with one or more risk factors may improve these rates.
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