ArticleTheranostics2014
Polyglycerolsulfate functionalized gold nanorods as optoacoustic signal nanoamplifiers for in vivo bioimaging of rheumatoid arthritis.
Article in Theranostics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis.Aging and disease · 2025Review
- Nanomaterial-assisted theranosis of bone diseases.Bioactive materials · 2023Review
- Icosahedral gold nanoparticles decorated with hexon protein: a surrogate for adenovirus serotype 5.Analytical and bioanalytical chemistry · 2023Article
- Dendritic Polyglycerol-Conjugated Gold Nanostars for Metabolism Inhibition and Targeted Photothermal Therapy in Breast Cancer Stem Cells.Advanced healthcare materials · 2022Article
- Nanotechnology for cardiovascular diseases.Innovation (Cambridge (Mass.)) · 2022Review
- Energy Conversion-Based Nanotherapy for Rheumatoid Arthritis Treatment.Frontiers in bioengineering and biotechnology · 2020Review
- Ceria-based nanotheranostic agent for rheumatoid arthritis.Theranostics · 2020Article
- Engineered nanoparticle bio-conjugates toxicity screening: The xCELLigence cells viability impact.BioImpacts : BI · 2020Review
- Applying dynamic contrast enhanced MSOT imaging to intratumoral pharmacokinetic modeling.Photoacoustics · 2018Article
- Charge and hydration structure of dendritic polyelectrolytes: molecular simulations of polyglycerol sulphate.Soft matter · 2018Article
- The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells.Frontiers in pharmacology · 2018Article
- Sonophore labeled RGD: a targeted contrast agent for optoacoustic imaging.Photoacoustics · 2017Article
- The influence of surface charge on serum protein interaction and cellular uptake: studies with dendritic polyglycerols and dendritic polyglycerol-coated gold nanoparticles.International journal of nanomedicine · 2017Article
- Current and Emerging Clinical Applications of Multispectral Optoacoustic Tomography (MSOT) in Oncology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Review
- Acidic pH-targeted chitosan capped mesoporous silica coated gold nanorods facilitate detection of pancreatic tumors via multispectral optoacoustic tomography.ACS biomaterials science & engineering · 2016Article
- Polyglycidol, Its Derivatives, and Polyglycidol-Containing Copolymers-Synthesis and Medical Applications.Polymers · 2016Review
- Dendritic Polymers for Theranostics.Theranostics · 2016Review
- Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles, Progress, and Prospects.Chemical reviews · 2015Review
- Sulfonated Polyethylenimine for Photosensitizer Conjugation and Targeting.Bioconjugate chemistry · 2015Article
- Three-photon luminescence of gold nanorods and its applications for high contrast tissue and deep in vivo brain imaging.Theranostics · 2015Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have synthesized a targeted imaging agent for rheumatoid arthritis based on polysulfated gold nanorods. The CTAB layer on gold nanorods was first replaced with PEG-thiol and then with dendritic polyglycerolsulfate at elevated temperature, which resulted in significantly reduced cytotoxicity compared to polyanionic gold nanorods functionalized by non-covalent approaches. In addition to classical characterization methods, we have established a facile UV-VIS based BaCl2 agglomeration assay to confirm a quantitative removal of unbound ligand. With the help of a competitive surface plasmon resonance-based L-selectin binding assay and a leukocyte adhesion-based flow cell assay, we have demonstrated the high inflammation targeting potential of the synthesized gold nanorods in vitro. In combination with the surface plasmon resonance band of AuNRs at 780 nm, these findings permitted the imaging of inflammation in an in vivo mouse model for rheumatoid arthritis with high contrast using multispectral optoacoustic tomography. The study offers a robust method for otherwise difficult to obtain covalently functionalized polyanionic gold nanorods, which are suitable for biological applications as well as a low-cost, actively targeted, and high contrast imaging agent for the diagnosis of rheumatoid arthritis. This paves the way for further research in other inflammation associated pathologies, in particular, when photothermal therapy can be applied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.