Evidence map›Paper›PMID 24723937›Full record

ReviewFrontiers in genetics2014

Regulation of metabolism by long, non-coding RNAs.

Jan-Wilhelm Kornfeld, Jens C Brüning

Abstract readReview
In one paragraph

Review in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Epigenetic Inheritance and Transgenerational Environmental Justice.The Yale journal of biology and medicine · 2023
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jan-Wilhelm KornfeldCologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases Köln, Germany ; Max-Planck-Institute for Neurological Research Köln, Germany.
Jens C BrüningCologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases Köln, Germany ; Max-Planck-Institute for Neurological Research Köln, Germany ; Department of Mouse Genetics and Metabolism and Center for Molecular Medicine Cologne, Institute for Genetics at the University Hospital of Cologne, University of Cologne Cologne, Germany ; Center for Endocrinology, Diabetes and Preventive Medicine, University Hospital Cologne, University of Cologne, Cologne Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our understanding of genomic regulation was revolutionized by the discovery that the genome is pervasively transcribed, giving rise to thousands of mostly uncharacterized non-coding ribonucleic acids (ncRNAs). Long, ncRNAs (lncRNAs) have thus emerged as a novel class of functional RNAs that impinge on gene regulation by a broad spectrum of mechanisms such as the recruitment of epigenetic modifier proteins, control of mRNA decay and DNA sequestration of transcription factors. We review those lncRNAs that are implicated in differentiation and homeostasis of metabolic tissues and present novel concepts on how lncRNAs might act on energy and glucose homeostasis. Finally, the control of circadian rhythm by lncRNAs is an emerging principles of lncRNA-mediated gene regulation.

Indexed as

cell differentiationglucose homeostasislncRNAsmetabolism and obesitynon-coding RNA (ncRNA)

Identifiers

PMID24723937
PMCPMC3971185

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.