ReviewFrontiers in psychology2014
Irrelevant stimulus processing in ADHD: catecholamine dynamics and attentional networks.
Review in Frontiers in psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Cognitive characterization of adult attention deficit hyperactivity disorder by domains: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2021Pooled it
- Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder.Translational psychiatry · 2018Trial
- Salience network coupling is linked to both tobacco smoking and symptoms of attention deficit hyperactivity disorder (ADHD).Drug and alcohol dependence · 2018Trial
- Neural correlates of inattention in adults with ADHD.European archives of psychiatry and clinical neuroscience · 2025Article
- Article
- Pupillary unrest is attenuated in attention deficit hyperactivity disorder (ADHD).Neuroscience letters · 2025Article
- Comparison of face attention bias in adults with ASD, ADHD, or comorbid ADHD+ASD.Social cognitive and affective neuroscience · 2025Article
- Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior.BMC psychiatry · 2025Article
- Can attention-deficit/hyperactivity disorder be considered a form of cerebellar dysfunction?Frontiers in neuroscience · 2025Article
- Greater Frontoparietal Connectivity During Task Engagement Among Toddlers With Parent-Reported Inattention.Developmental psychobiology · 2024Article
- Gaze measurements during viewing human dialogue scenes in adults with ADHD: Preliminary findings.Neuropsychopharmacology reports · 2024Article
- Pupillary dilations in a Target/Distractor visual task paradigm and attention deficit hyperactivity disorder (ADHD).Neuroscience letters · 2024Article
- Article
- Genetic and environmental factors influencing neonatal resting-state functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Arousal dysregulation and executive dysfunction in attention deficit hyperactivity disorder (ADHD).Frontiers in psychiatry · 2023Article
- Normative model detects abnormal functional connectivity in psychiatric disorders.Frontiers in psychiatry · 2023Article
- Article
- Neurodevelopmental Disorders and Risk of Concussion: Findings from the National Collegiate Athletic Association Department of Defense Grand Alliance Concussion Assessment, Research, and Education (NCAA-DOD CARE) Consortium (2014-2017).Journal of neurotrauma · 2022Article
- Catecholaminergic and cholinergic neuromodulation in autism spectrum disorder: A comparison to attention-deficit hyperactivity disorder.Frontiers in neuroscience · 2022Review
- Gray Matter Network Associated With Attention in Children With Attention Deficit Hyperactivity Disorder.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
A cardinal symptom of attention deficit and hyperactivity disorder (ADHD) is a general distractibility where children and adults shift their attentional focus to stimuli that are irrelevant to the ongoing behavior. This has been attributed to a deficit in dopaminergic signaling in cortico-striatal networks that regulate goal-directed behavior. Furthermore, recent imaging evidence points to an impairment of large scale, antagonistic brain networks that normally contribute to attentional engagement and disengagement, such as the task-positive networks and the default mode network (DMN). Related networks are the ventral attentional network (VAN) involved in attentional shifting, and the salience network (SN) related to task expectancy. Here we discuss the tonic-phasic dynamics of catecholaminergic signaling in the brain, and attempt to provide a link between this and the activities of the large-scale cortical networks that regulate behavior. More specifically, we propose that a disbalance of tonic catecholamine levels during task performance produces an emphasis of phasic signaling and increased excitability of the VAN, yielding distractibility symptoms. Likewise, immaturity of the SN may relate to abnormal tonic signaling and an incapacity to build up a proper executive system during task performance. We discuss different lines of evidence including pharmacology, brain imaging and electrophysiology, that are consistent with our proposal. Finally, restoring the pharmacodynamics of catecholaminergic signaling seems crucial to alleviate ADHD symptoms; however, the possibility is open to explore cognitive rehabilitation strategies to top-down modulate network dynamics compensating the pharmacological deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.