ReviewFrontiers in physiology2014
Building a brain under nutritional restriction: insights on sparing and plasticity from Drosophila studies.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Fat body CLOCK restrains innate immunity and maintains survival under dietary stress inbioRxiv : the preprint server for biology · 2026Article
- Invertebrate glial barriers as a model for understanding blood-brain barrier evolution.Fluids and barriers of the CNS · 2025Review
- Comparative single-cell transcriptomic atlases of drosophilid brains suggest glial evolution during ecological adaptation.PLoS biology · 2025Article
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- Drosophila postembryonic nervous system development: a model for the endocrine control of development.Genetics · 2023Review
- Maintaining robust size across environmental conditions through plastic brain growth dynamics.Open biology · 2022Article
- The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Balancing energy expenditure and storage with growth and biosynthesis during Drosophila development.Developmental biology · 2021Review
- Integrating animal development: How hormones and metabolism regulate developmental transitions and brain formation.Developmental biology · 2021Review
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- Light Stimuli and Circadian Clock Affect Neural Development inFrontiers in cell and developmental biology · 2021Article
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- No gains for bigger brains: Functional and neuroanatomical consequences of relative brain size in a parasitic wasp.Journal of evolutionary biology · 2019Article
- p53 is required for brain growth but is dispensable for resistance to nutrient restriction during Drosophila larval development.PloS one · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the growth of the developing brain is known to be well-protected compared to other organs in the face of nutrient restriction (NR), careful analysis has revealed a range of structural alterations and long-term neurological defects. Yet, despite intensive studies, little is known about the basic principles that govern brain development under nutrient deprivation. For over 20 years, Drosophila has proved to be a useful model for investigating how a functional nervous system develops from a restricted number of neural stem cells (NSCs). Recently, a few studies have started to uncover molecular mechanisms as well as region-specific adaptive strategies that preserve brain functionality and neuronal repertoire under NR, while modulating neuron numbers. Here, we review the developmental constraints that condition the response of the developing brain to NR. We then analyze the recent Drosophila work to highlight key principles that drive sparing and plasticity in different regions of the central nervous system (CNS). As simple animal models start to build a more integrated picture, understanding how the developing brain copes with NR could help in defining strategies to limit damage and improve brain recovery after birth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.