ArticleFrontiers in neural circuits2014
Different roles of axon guidance cues and patterned spontaneous activity in establishing receptive fields in the mouse superior colliculus.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Activation of multiple Eph receptors on neuronal membranes correlates with the onset of optic neuropathy.Eye and vision (London, England) · 2023Article
- Activation of Multiple Eph Receptors on Neuronal Membranes Correlates with The Onset of Traumatic Optic Neuropathy.bioRxiv : the preprint server for biology · 2023Article
- Lack of Evidence for Stereotypical Direction Columns in the Mouse Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Visual subcircuit-specific dysfunction and input-specific mispatterning in the superior colliculus of fragile X mice.Journal of neurodevelopmental disorders · 2018Article
- The Mouse Superior Colliculus as a Model System for Investigating Cell Type-Based Mechanisms of Visual Motor Transformation.Frontiers in neural circuits · 2018Article
- Activity-dependent development of visual receptive fields.Current opinion in neurobiology · 2017Review
- Ephrin-As are required for the topographic mapping but not laminar choice of physiologically distinct RGC types.Developmental neurobiology · 2015Article
- Neurons in the most superficial lamina of the mouse superior colliculus are highly selective for stimulus direction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Progressive degeneration of retinal and superior collicular functions in mice with sustained ocular hypertension.Investigative ophthalmology & visual science · 2015Article
- Editorial: What can simple brains teach us about how vision works.Frontiers in neural circuits · 2015Article
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3 authors.
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Abstract
Visual neurons in the superior colliculus (SC) respond to both bright (On) and dark (Off) stimuli in their receptive fields. This receptive field property is due to proper convergence of On- and Off-centered retinal ganglion cells to their target cells in the SC. In this study, we have compared the receptive field structure of individual SC neurons in two lines of mutant mice that are deficient in retinotopic mapping: the ephrin-A knockouts that lack important retinocollicular axonal guidance cues and the nAChR-β2 knockouts that have altered activity-dependent refinement of retinocollicular projections. We find that even though the receptive fields are much larger in the ephrin-A knockouts, their On-Off overlap remains unchanged. These neurons also display normal level of selectivity for stimulus direction and orientation. In contrast, the On-Off overlap is disrupted in the β2 knockouts. Together with the previous finding of disrupted direction and orientation selectivity in the β2 knockout mice, our results indicate that molecular guidance cues and activity-dependent processes play different roles in the development of receptive field properties in the SC.
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