ArticleFrontiers in neural circuits2014
Dynamical criticality during induction of anesthesia in human ECoG recordings.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A methodological guideline for consciousness assessment via neural electrophysiological activity.Military Medical Research · 2025Guideline
- Is criticality a unified setpoint of brain function?Neuron · 2025Pooled it
- Neuronal Dynamics During Isoflurane Induction inbioRxiv : the preprint server for biology · 2026Article
- Cortical Mechanisms Contributing to Ketamine-Induced Dissociation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026Review
- Adaptation modulates effective connectivity and network stability.Frontiers in computational neuroscience · 2026Article
- Shifts in brain dynamics and drivers of consciousness state transitions.Frontiers in computational neuroscience · 2026Article
- Criticality and increased intrinsic neural timescales in stroke.NPJ systems biology and applications · 2025Article
- Aperiodic neural dynamics define a novel signature of glioma-induced excitation-inhibition dysregulation.bioRxiv : the preprint server for biology · 2025Article
- The Administration of Ketamine Is Associated with Dose-Dependent Stabilization of Cortical Dynamics in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Macroscopic quantum effects in the brain: new insights into the fundamental principle underlying conscious processes.Frontiers in human neuroscience · 2025Article
- Article
- Anesthesia and the neurobiology of consciousness.Neuron · 2024Review
- Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena.Cell reports · 2023Article
- Quasiuniversal scaling in mouse-brain neuronal activity stems from edge-of-instability critical dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A scoping review for building a criticality-based conceptual framework of altered states of consciousness.Frontiers in systems neuroscience · 2023Article
- Robustness and Flexibility of Neural Function through Dynamical Criticality.Entropy (Basel, Switzerland) · 2022Review
- How general anesthetics work: from the perspective of reorganized connections within the brain.Korean journal of anesthesiology · 2022Review
- Signatures of Thalamocortical Alpha Oscillations and Synchronization With Increased Anesthetic Depths Under Isoflurane.Frontiers in pharmacology · 2022Article
- Self-organized criticality as a framework for consciousness: A review study.Frontiers in psychology · 2022Article
- Explaining anaesthetic hysteresis with effect-site equilibration.British journal of anaesthesia · 2021Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
In this work we analyze electro-corticography (ECoG) recordings in human subjects during induction of anesthesia with propofol. We hypothesize that the decrease in responsiveness that defines the anesthetized state is concomitant with the stabilization of neuronal dynamics. To test this hypothesis, we performed a moving vector autoregressive analysis and quantified stability of neuronal dynamics using eigenmode decomposition of the autoregressive matrices, independently fitted to short sliding temporal windows. Consistent with the hypothesis we show that while the subject is awake, many modes of neuronal activity oscillations are found at the edge of instability. As the subject becomes anesthetized, we observe statistically significant increase in the stability of neuronal dynamics, most prominently observed for high frequency oscillations. Stabilization was not observed in phase randomized surrogates constructed to preserve the spectral signatures of each channel of neuronal activity. Thus, stability analysis offers a novel way of quantifying changes in neuronal activity that characterize loss of consciousness induced by general anesthetics.
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Registered trials
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