ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2014
Major depressive disorder and bone mass in adolescents and young adults.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Calcium and Vitamin D Supplementation in Boys with Risperidone-Induced Hyperprolactinemia: A Randomized, Placebo-Controlled Pilot Study.Journal of child and adolescent psychopharmacology · 2018Trial
- Repeated social defeat causes bone loss from mouse femur.Brain, behavior, & immunity - health · 2026Article
- Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast.eLife · 2025Article
- Depression predicts decreased lumbar bone mineral density: A scoping review of chronic psychological stress and spinal tissue pathology.Osteoarthritis and cartilage open · 2024Article
- Problematic video gaming is negatively associated with bone mineral density in adolescents.European journal of pediatrics · 2024Article
- Major depressive disorder elevates the risk of dentofacial deformity: a bidirectional two-sample Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Fracture healing research: Recent insights.Bone reports · 2023Review
- Examining Whether Genetic Variants Moderate the Skeletal Effects of Selective Serotonin Reuptake Inhibitors in Older Adolescents and Young Adults.Journal of child and adolescent psychopharmacology · 2023Observational
- Neutrophil-derived catecholamines mediate negative stress effects on bone.Nature communications · 2023Article
- Association of bone mineral density and depression in different bone sites and ages: A meta-analysis.Food science & nutrition · 2021Article
- Gut microbiome in adolescent depression.Journal of affective disorders · 2021Article
- Inflammatory Markers Profile in Older Adolescents During Treatment with Selective Serotonin Reuptake Inhibitors.Journal of child and adolescent psychopharmacology · 2021Observational
- Predictors of depressive symptom trajectories in a prospective follow-up of late adolescents.Psychological medicine · 2020Article
- Selective serotonin reuptake inhibitors (SSRI) affect murine bone lineage cells.Life sciences · 2020Article
- Effects of Neurological Disorders on Bone Health.Frontiers in psychology · 2020Review
- Experiential Avoidance Predicts Persistence of Major Depressive Disorder and Generalized Anxiety Disorder in Late Adolescence.The Journal of clinical psychiatry · 2019Article
- Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Impact of Psychotropic Medications on Bone Health in Youth.Current psychiatry reports · 2018Review
- The effect of depression on fracture healing and osteoblast differentiation in rats.Neuropsychiatric disease and treatment · 2018Article
- The Role of the Intestinal Microbiome in Chronic Psychosocial Stress-Induced Pathologies in Male Mice.Frontiers in behavioral neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Depression has been associated with reduced bone mass in adults, but the mechanisms remain unclear. In addition, little is known about the association between depression and bone health during growth and development. To address this knowledge gap, we examined bone density and structure in 222 adolescents and young adults (69% females, mean ± SD age: 19.0 ± 1.5 years), enrolled within 1 month of starting a selective serotonin reuptake inhibitor (SSRI) or unmedicated. Psychiatric functioning was assessed with self-report and researcher-administered instruments, including the Longitudinal Interval Follow-up Evaluation for Adolescents (A-LIFE). Anthropometric and laboratory measures included dual-energy x-ray absorptiometry and peripheral quantitative computed tomography scans. Linear multivariable regression analysis tested the association between depression and bone mass, after accounting for relevant confounders. The presence of current depression was associated with a significant reduction in age-sex-height-race-specific bone mineral density (BMD) and content (BMC) of total body less head and lumbar spine. The findings varied by assessment method with self-report scales, capturing symptom severity over the prior week or two, yielding the weakest associations. Depression was also associated with reduced cortical thickness and a trend for increased endosteal circumference. In contrast, generalized anxiety disorder was not associated with bone deficits. In sum, depressive illness is associated with significantly lower bone mass in youths. Future investigations must examine whether bone recovery is possible following depression remission or whether remedial interventions are warranted to optimize bone mass in order to minimize the long-term risk of osteoporosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.