ArticleJournal of experimental botany2014
The Arabidopsis transcription factor IIB-related protein BRP4 is involved in the regulation of mitotic cell-cycle progression during male gametogenesis.
Article in Journal of experimental botany, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- A critical role of a plant-specific TFIIB-related protein, BRP1, in salicylic acid-mediated immune response.Frontiers in plant science · 2024Article
- TFIIB-Related Protein BRP5/PTF2 Is Required for Both Male and Female Gametogenesis and for Grain Formation in Rice.International journal of molecular sciences · 2023Article
- Degradome Analysis of Tomato andInternational journal of molecular sciences · 2021Article
- Expansion and Functional Diversification of TFIIB-Like Factors in Plants.International journal of molecular sciences · 2021Review
- Effects of graphene on morphology, microstructure and transcriptomic profiling of Pinus tabuliformis Carr. roots.PloS one · 2021Article
- ARG1 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight.Astrobiology · 2017Article
- The plant cell cycle: Pre-Replication complex formation and controls.Genetics and molecular biology · 2017Article
- Regulatory Networks in Pollen Development under Cold Stress.Frontiers in plant science · 2016Review
- The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis.PLoS genetics · 2015Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male gametogenesis in angiosperms involves two rounds of mitosis that are essential for the generation of two sperm cells to achieve double fertilization, a distinct event in the sexual reproduction of flowering plants. Precise regulation of mitosis during male gametogenesis is critically important for the establishment of the male germline. However, the molecular mechanisms underlying mitotic division during male gametophyte development have not been characterized fully. Here, we report that the Arabidopsis transcription initiation factor TFIIB-related protein BRP4 is involved in the regulation of mitotic cell-cycle progression during male gametogenesis. BRP4 was expressed predominately in developing male gametophytes. Knockdown expression of BRP4 by a native promoter-driven RNA interference construct in Arabidopsis resulted in arrest of the mitotic progression of male gametophytes, leading to a defect in pollen development. Moreover, we showed that the level of expression of a gene encoding a subunit of the origin recognition complex, ORC6, was decreased in BRP4 knockdown plants, and that the ORC6 knockdown transgenic plants phenocopied the male gametophyte defect observed in BRP4 knockdown plants, suggesting that ORC6 acts downstream of BRP4 to mediate male mitotic progression. Taken together, our results reveal that BRP4 plays an important role in the regulation of mitotic cell-cycle progression during male gametogenesis.
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