ArticleEuropean journal of immunology2014
A novel T-cell receptor mimic defines dendritic cells that present an immunodominant West Nile virus epitope in mice.
Article in European journal of immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Multi-antigen DNA vaccine targeting non-structural proteins confers robust T Cell-mediated protection against Zika virus.NPJ vaccines · 2026Article
- West Nile virus triggers intestinal dysmotility via T cell-mediated enteric nervous system injury.The Journal of clinical investigation · 2024Article
- A diversified role for γδT cells in vector-borne diseases.Frontiers in immunology · 2022Review
- TCR Transgenic Mice: A Valuable Tool for Studying Viral Immunopathogenesis Mechanisms.International journal of molecular sciences · 2020Review
- Dynamics of Tissue-Specific CD8Journal of virology · 2018Article
- Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections.Cell reports · 2018Article
- Opportunities and challenges for TCR mimic antibodies in cancer therapy.Expert opinion on biological therapy · 2016Review
- Immunodominant West Nile Virus T Cell Epitopes Are Fewer in Number and Fashionably Late.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Functional evidence for TCR-intrinsic specificity for MHCII.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Direct interrogation of viral peptides presented by the class I HLA of HIV-infected T cells.Journal of virology · 2014Article
- Self-Induced Back-Action Actuated Nanopore Electrophoresis (SANE) Sensor for Label-Free Detection of Cancer Immunotherapy-Relevant Antibody-Ligand Interactions.Methods in molecular biology (Clifton, N.J.)Article
- T cell receptor mimic antibodies for cancer therapy.OncoimmunologyReview
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
We used a newly generated T-cell receptor mimic monoclonal antibody (TCRm MAb) that recognizes a known nonself immunodominant peptide epitope from West Nile virus (WNV) NS4B protein to investigate epitope presentation after virus infection in C57BL/6 mice. Previous studies suggested that peptides of different length, either SSVWNATTAI (10-mer) or SSVWNATTA (9-mer) in complex with class I MHC antigen H-2D(b) , were immunodominant after WNV infection. Our data establish that both peptides are presented on the cell surface after WNV infection and that CD8(+) T cells can detect 10- and 9-mer length variants similarly. This result varies from the idea that a given T-cell receptor (TCR) prefers a single peptide length bound to its cognate class I MHC. In separate WNV infection studies with the TCRm MAb, we show that in vivo the 10-mer was presented on the surface of uninfected and infected CD8α(+) CD11c(+) dendritic cells, which suggests the use of direct and cross-presentation pathways. In contrast, CD11b(+) CD11c(-) cells bound the TCRm MAb only when they were infected. Our study demonstrates that TCR recognition of peptides is not limited to certain peptide lengths and that TCRm MAbs can be used to dissect the cell-type specific mechanisms of antigen presentation in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.