SynthesisClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014
Prevention of central line-associated bloodstream infections through quality improvement interventions: a systematic review and meta-analysis.
Synthesis in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06085690 (A Multicenter Clinical Translational Study of "ICU-NO CRBSI" Based on Improvement Science in China), which is not on this map. Cited by 65 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Clinical Translational Study of "ICU-NO CRBSI" Based on Improvement Science in China
Who cites it
65 citing papers in PubMed, 7 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- Prevalence of healthcare-associated infections in developing and developed countries: a systematic review.BMC infectious diseases · 2026Pooled it
- Is there a way to reduce the infection associated with external ventricular shunts? A systematic review and meta-analysis of the recent bundle of care.Neurosurgical review · 2026Pooled it
- Candidemia Following Severe COVID-19 in Hospitalised and Critical Ill Patients: A Systematic Review and Meta-Analysis.Mycoses · 2024Pooled it
- Infection Prevention in the Neurointensive Care Unit: A Systematic Review.Neurocritical care · 2019Pooled it
- The impact of chlorhexidine bathing on hospital-acquired bloodstream infections: a systematic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- Economic Evaluation of Quality Improvement Interventions for Bloodstream Infections Related to Central Catheters: A Systematic Review.JAMA internal medicine · 2016Pooled it
- Prevention of hospital-acquired bloodstream infections through chlorhexidine gluconate-impregnated washcloth bathing in intensive care units: a systematic review and meta-analysis of randomised crossover trials.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2016Pooled it
- Prevention of hospital infections by intervention and training (PROHIBIT): results of a pan-European cluster-randomized multicentre study to reduce central venous catheter-related bloodstream infections.Intensive care medicine · 2018Trial
- A National Collaborative Project to Decrease Healthcare-Associated Infections in Intensive Care Units: Results from Stop Hospital Infection, in Portugal.Antibiotics (Basel, Switzerland) · 2026Article
- Article
- A quality improvement initiative to reduce central line-associated bloodstream infection rates in the polytrauma intensive care unit of a tertiary care trauma hospital in India.Infection prevention in practice · 2026Article
- Early detection of vascular catheter-associated infections employing supervised machine learning - a case study in Lleida region.BMC medical informatics and decision making · 2025Article
- Barriers and facilitators to disseminating quality improvement and patient safety research: a scoping review.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2025Article
- Impact of a care bundle on short peripheral catheter-associated complications in a resource-limited neonatal unit.The journal of vascular access · 2025Article
- Incidence, Compliance, and Risk Factor Associated with Central Line-Associated Bloodstream Infection (CLABSI) in Intensive Care Unit (ICU) Patients: A Multicenter Study in an Upper Middle-Income Country.Antibiotics (Basel, Switzerland) · 2025Article
- Prevention of Catheter-Related Infections and Complications: A Narrative Literature Review of Vascular Care and Maintenance.International journal of vascular medicine · 2025Review
- Central venous catheter care and the healthcare-environment interface: outcomes of a quality improvement initiative in a resource-constrained ICU.Frontiers in public health · 2025Article
- Digital Maturity as a Predictor of Quality and Safety Outcomes in US Hospitals: Cross-Sectional Observational Study.Journal of medical Internet research · 2024Observational
- Bundle care approach to reduce device associated infections in post-living-donor-liver transplantation in a tertiary care hospital, Egypt.BMC infectious diseases · 2024Article
- The use of checklists in the intensive care unit: a scoping review.Critical care (London, England) · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis examines the impact of quality improvement interventions on central line-associated bloodstream infections in adult intensive care units. Studies were identified through Medline and manual searches (1995-June 2012). Random-effects meta-analysis obtained pooled odds ratios (ORs) and 95% confidence intervals (CIs). Meta-regression assessed the impact of bundle/checklist interventions and high baseline rates on intervention effect. Forty-one before-after studies identified an infection rate decrease (OR, 0.39 [95% CI, .33-.46]; P < .001). This effect was more pronounced for trials implementing a bundle or checklist approach (P = .03). Furthermore, meta-analysis of 6 interrupted time series studies revealed an infection rate reduction 3 months postintervention (OR, 0.30 [95% CI, .10-.88]; P = .03). There was no difference in infection rates between studies with low or high baseline rates (P = .18). These results suggest that quality improvement interventions contribute to the prevention of central line-associated bloodstream infections. Implementation of care bundles and checklists appears to yield stronger risk reductions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.