Evidence map›Paper›PMID 24723258›Full record

SynthesisEndocrine2014

Associations between rs965513/rs944289 and papillary thyroid carcinoma risk: a meta-analysis.

Lizhe Ai, Xiaoli Liu, Yuhang Yao, Yaqin Yu, Hui Sun, Qiong Yu

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Endocrine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Review
  7. Article
  8. MYH9 binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk locus.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  9. Article
  10. INTEGRATING CLINICAL LABORATORY MEASURES AND ICD-9 CODE DIAGNOSES IN PHENOME-WIDE ASSOCIATION STUDIES.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2016
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lizhe AiDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
Xiaoli Liu
Yuhang Yao
Yaqin Yu
Hui Sun
Qiong Yu
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-nucleotide polymorphisms of rs965513 (9q22.33) and rs944289 (14q13.3) may be involved in the pathogenesis of papillary thyroid carcinoma (PTC). But, relevant genetic studies reported different results. The aim of this meta-analysis was to derive a more precise assessment of the association of rs965513/rs944289 polymorphism with PTC risk. Relevant studies were identified using PubMed, ISI Web of knowledge, Medline, Embase, Google Scholar Search database, SinoMed (Chinese), CNKI (Chinese), GeNii (Japanese) and ICHUSHI (Japanese) (update to December, 2013). A total of eight case-control studies with 52,363 subjects for rs965513 and 51,120 subjects for rs944289 were included. The results showed significant associations of rs965513/rs944289 with PTC risk existed in overall population (for rs965513, A vs. G: OR 1.71 (1.56-1.86); for rs944289, T vs. C: OR 1.29 (1.23-1.37)). Subgroup analysis by ethnicity showed that there were significant associations in Asians (for rs965513, A vs. G: OR 1.48 (1.27-1.73); for rs944289, T vs. C: OR 1.35 (1.18-1.55)), in Europeans (for rs965513, A vs. G: OR 1.74 (1.61-1.88); for rs944289, T vs. C: OR 1.24 (1.14-1.34)), and in Americans (for rs965513, A vs. G: OR 2.00 (1.76-2.27); for rs944289, T vs. C: OR 1.29 (1.14-1.47)). In conclusion, Rs965513 [A] and rs944289 [T] are risk factors of PTC. Effect estimate for rs965513 polymorphism is higher in Americans than in Asians.

Indexed as

Genetic LociGenetic Predisposition to DiseasePolymorphism, Single NucleotideCarcinoma, PapillaryGenetic Association StudiesGenotypeHumansThyroid Neoplasms

Identifiers

PMID24723258
OpenAlexW2038746963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.