ArticleBrain structure & function2015
An anterograde rabies virus vector for high-resolution large-scale reconstruction of 3D neuron morphology.
Article in Brain structure & function, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons.Neuron · 2022Article
- Smart imaging to empower brain-wide neuroscience at single-cell levels.Brain informatics · 2022Review
- Glycoproteins of Predicted Amphibian and Reptile Lyssaviruses Can Mediate Infection of Mammalian and Reptile Cells.Viruses · 2021Article
- Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses.Neuroscience bulletin · 2019Review
- Hippocampal Mossy Fibers Synapses in CA3 Pyramidal Cells Are Altered at an Early Stage in a Mouse Model of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Optimization of the Fluorescent Protein Expression Level Based on Pseudorabies Virus Bartha Strain for Neural Circuit Tracing.Frontiers in neuroanatomy · 2019Article
- Dysfunctional Autism Risk Genes Cause Circuit-Specific Connectivity Deficits With Distinct Developmental Trajectories.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus.Scientific reports · 2018Article
- Virus stamping for targeted single-cell infection in vitro and in vivo.Nature biotechnology · 2018Article
- Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System.Frontiers in neuroanatomy · 2017Article
- Supernova: A Versatile Vector System for Single-Cell Labeling and Gene Function Studies in vivo.Scientific reports · 2016Article
- Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors.Nature communications · 2016Article
- Increasing the effectiveness of intracerebral injections in adult and neonatal mice: a neurosurgical point of view.Neuroscience bulletin · 2015Article
- Structural-functional connectivity deficits of neocortical circuits in the Fmr1 (-/y) mouse model of autism.Science advances · 2015Article
- Axonal spread of neuroinvasive viral infections.Trends in microbiology · 2015Review
- Anterograde glycoprotein-dependent transport of newly generated rabies virus in dorsal root ganglion neurons.Journal of virology · 2014Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycoprotein-deleted rabies virus (RABV ∆G) is a powerful tool for the analysis of neural circuits. Here, we demonstrate the utility of an anterograde RABV ∆G variant for novel neuroanatomical approaches involving either bulk or sparse neuronal populations. This technology exploits the unique features of RABV ∆G vectors, namely autonomous, rapid high-level expression of transgenes, and limited cytotoxicity. Our vector permits the unambiguous long-range and fine-scale tracing of the entire axonal arbor of individual neurons throughout the brain. Notably, this level of labeling can be achieved following infection with a single viral particle. The vector is effective over a range of ages (>14 months) aiding the studies of neurodegenerative disorders or aging, and infects numerous cell types in all brain regions tested. Lastly, it can also be readily combined with retrograde RABV ∆G variants. Together with other modern technologies, this tool provides new possibilities for the investigation of the anatomy and physiology of neural circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.