ArticlePLoS pathogens2014
pelo is required for high efficiency viral replication.
Article in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Pelota: A double-edged sword in virus infection.PLoS pathogens · 2025Review
- Insights into Virus-Host Interactions: Lessons from Caenorhabditis elegans-Orsay Virus Model.Current medical science · 2025Review
- The tomato gene Ty-6, encoding DNA polymerase delta subunit 1, confers broad resistance to Geminiviruses.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Microbial gatekeepers: midgut bacteria inFrontiers in microbiology · 2025Review
- Insect ribosome-rescuer Pelo-Hbs1 complex on sperm surface mediates paternal arbovirus transmission.Nature communications · 2024Article
- A comprehensive review ofFrontiers in immunology · 2024Review
- Article
- Translational regulation by ribosome-associated quality control in neurodegenerative disease, cancer, and viral infection.Frontiers in cell and developmental biology · 2022Review
- A recessive gene pepy-1 encoding Pelota confers resistance to begomovirus isolates of PepYLCIV and PepYLCAV in Capsicum annuum.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- The Global Dimension of Tomato Yellow Leaf Curl Disease: Current Status and Breeding Perspectives.Microorganisms · 2021Review
- Roadblocks and fast tracks: How RNA binding proteins affect the viral RNA journey in the cell.Seminars in cell & developmental biology · 2021Review
- WSV056 Inhibits Shrimp Nitric Oxide Synthase Activity by DownregulatingFrontiers in microbiology · 2021Article
- A Pelota-like gene regulates root development and defence responses in rice.Annals of botany · 2018Article
- Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.Cell metabolism · 2018Article
- Defense Mechanisms against Viral Infection inViruses · 2018Review
- Suppression of the pelo protein by Wolbachia and its effect on dengue virus in Aedes aegypti.PLoS neglected tropical diseases · 2018Article
- Disruption of Stress Granule Formation by the Multifunctional Cricket Paralysis Virus 1A Protein.Journal of virology · 2017Article
- Viral Evasion and Manipulation of Host RNA Quality Control Pathways.Journal of virology · 2016Review
- Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viruses hijack host factors for their high speed protein synthesis, but information about these factors is largely unknown. In searching for genes that are involved in viral replication, we carried out a forward genetic screen for Drosophila mutants that are more resistant or sensitive to Drosophila C virus (DCV) infection-caused death, and found a virus-resistant line in which the expression of pelo gene was deficient. Our mechanistic studies excluded the viral resistance of pelo deficient flies resulting from the known Drosophila anti-viral pathways, and revealed that pelo deficiency limits the high level synthesis of the DCV capsid proteins but has no or very little effect on the expression of some other viral proteins, bulk cellular proteins, and transfected exogenous genes. The restriction of replication of other types of viruses in pelo deficient flies was also observed, suggesting pelo is required for high level production of capsids of all kinds of viruses. We show that both pelo deficiency and high level DCV protein synthesis increase aberrant 80S ribosomes, and propose that the preferential requirement of pelo for high level synthesis of viral capsids is at least partly due to the role of pelo in dissociation of stalled 80S ribosomes and clearance of aberrant viral RNA and proteins. Our data demonstrated that pelo is a host factor that is required for high efficiency translation of viral capsids and targeting pelo could be a strategy for general inhibition of viral infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.