Evidence map›Paper›PMID 24722726›Full record

ArticlePloS one2014

Recombination in the evolution of enterovirus C species sub-group that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99.

Teemu Smura, Soile Blomqvist, Tytti Vuorinen, Olga Ivanova, Elena Samoilovich, Haider Al-Hello, Carita Savolainen-Kopra, Tapani Hovi, Merja Roivainen

Abstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  18. Allosteric inhibitors of Coxsackie virus A24 RNA polymerase.Bioorganic & medicinal chemistry · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Teemu SmuraNational Institute for Health and Welfare (THL), Helsinki, Finland; Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Soile BlomqvistNational Institute for Health and Welfare (THL), Helsinki, Finland.
Tytti VuorinenDepartment of Virology, University of Turku, Turku, Finland.
Olga IvanovaM.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences, Moscow, Russia.
Elena SamoilovichRepublican Research and Practical Center for Epidemiology and Microbiology, Minsk, Republic of Belarus.
Haider Al-HelloNational Institute for Health and Welfare (THL), Helsinki, Finland.
Carita Savolainen-KopraNational Institute for Health and Welfare (THL), Helsinki, Finland.
Tapani HoviNational Institute for Health and Welfare (THL), Helsinki, Finland.
Merja RoivainenNational Institute for Health and Welfare (THL), Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic recombination is considered to be a very frequent phenomenon among enteroviruses (Family Picornaviridae, Genus Enterovirus). However, the recombination patterns may differ between enterovirus species and between types within species. Enterovirus C (EV-C) species contains 21 types. In the capsid coding P1 region, the types of EV-C species cluster further into three sub-groups (designated here as A-C). In this study, the recombination pattern of EV-C species sub-group B that contains types CVA-21, CVA-24, EV-C95, EV-C96 and EV-C99 was determined using partial 5'UTR and VP1 sequences of enterovirus strains isolated during poliovirus surveillance and previously published complete genome sequences. Several inter-typic recombination events were detected. Furthermore, the analyses suggested that inter-typic recombination events have occurred mainly within the distinct sub-groups of EV-C species. Only sporadic recombination events between EV-C species sub-group B and other EV-C sub-groups were detected. In addition, strict recombination barriers were inferred for CVA-21 genotype C and CVA-24 variant strains. These results suggest that the frequency of inter-typic recombinations, even within species, may depend on the phylogenetic position of the given viruses.

Indexed as

Evolution, MolecularRecombination, GeneticCapsid ProteinsEnterovirus C, HumanEnterovirus InfectionsGenome, ViralPhylogenyRNA, ViralCapsid ProteinsRNA, Viral

Identifiers

PMID24722726
PMCPMC3983234

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.