ArticleInvestigative ophthalmology & visual science2014
Age distribution of various corneal diseases in China by histopathological examination of 3112 surgical specimens.
Article in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 10 citations in OpenAlex.
- Changing indications for and trends of keratoplasty in a tertiary comprehensive hospital in northern part of China from 2002 to 2021: a 20-year review.BMC ophthalmology · 2024Article
- Oral voriconazole monotherapy for fungal keratitis: efficacy, safety, and factors associated with outcomes.Frontiers in medicine · 2023Article
- Evaluation of the Genetic Variation Spectrum Related to Corneal Dystrophy in a Large Cohort.Frontiers in cell and developmental biology · 2021Article
- Histone deacetylase inhibitor attenuates experimental fungal keratitis in mice.Scientific reports · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo analyze the age distribution of corneal disease in China by histopathological examination.
methodsA retrospective histopathological analysis of the prevalence and age distribution of corneal disease was performed on corneal specimens from 3112 patients who underwent corneal surgery between 2001 and 2012 in the Henan Eye Institute.
resultsInfectious keratitis (2212 specimens, 71.08%) was the most common corneal disease. The distribution of age groups was significantly higher after age 30 (16.29%), reaching a peak by age 40 (22.04%) and remaining high until age 59 (21.05%, P < 0.01). The highest age-specific percentage of corneal infection was between the ages of 50 and 59 (83.21%, P < 0.01). Noninfectious corneal diseases occurred mainly in the age range of 10 to 19 years (42.47%) and 20 to 29 years (40.78%). Between the ages of 10 and 19, the leading pathologic diagnosis was keratoconus, accounting for 21.29% of cases. In patients aged 80 and older, the most common noninfectious corneal diseases were Terrien-marginal degeneration (8.33%) and Mooren's ulcer (4.17%). The highest incidence of corneal tumor was seen between the ages of 0 and 9 years (65.83%) and age 80 and older (45.86%; P < 0.01).
conclusionsThe age distribution of corneal diseases in the Chinese population is distinct from other countries. The corneal diseases tend to increase in prevalence in middle age, especially for infectious corneal disease. The prevalence of corneal tumor is high in early and late life. Corneal degenerative disease occurs predominately in seniors.
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