Evidence map›Paper›PMID 24722649›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2014

The effects of caffeine on heart rate variability in newborns with apnea of prematurity.

I Ulanovsky, N S Haleluya, S Blazer, A Weissman

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  3. Observational
  4. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

I UlanovskyDepartments of Neonatology, Rambam Health Care Campus, Technion-Israel Institute of Technology, Haifa, Israel.
N S HaleluyaRappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
S Blazer1] Departments of Neonatology, Rambam Health Care Campus, Technion-Israel Institute of Technology, Haifa, Israel [2] Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
A Weissman1] Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel [2] Department of Obstetrics and Gynecology, Rambam Health Care Campus, Technion-Israel Institute of Technology, Haifa, Israel.
Technion – Israel Institute of Technology · ILRambam Health Care Campus · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveApnea of prematurity is a common complication in premature newborns and caffeine is a widespread medication used to treat this complication. Caffeine may have adverse effects on the cardiovascular and central nervous system, yet its effects on the autonomic nervous system modulation of heart rate have not been studied in premature newborns, which was the objective of our study. STUDY

designWe prospectively studied 21 premature newborns who were treated with caffeine. We analyzed heart rate variability by power spectral density and by dynamic nonlinear analyses methods.

resultThere were no changes in heart rate, blood pressure or the autonomic nervous system tone following administration of caffeine, nor were the nonlinear dynamical properties of the system altered by caffeine.

conclusionCaffeine does not have detrimental effects on heart rate variability, heart rate or blood pressure in conventional doses given to premature newborns.

Indexed as

ApneaCaffeineCentral Nervous System StimulantsFemaleHeart RateHumansInfant, NewbornInfant, PrematureInfant, Premature, DiseasesMaleProspective StudiesCaffeineCentral Nervous System Stimulants

Identifiers

PMID24722649
OpenAlexW2043187508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.