Trial reportInternational clinical psychopharmacology2014
Venlafaxine extended-release treatment of hoarding disorder.
Trial report in International clinical psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 69 citations in OpenAlex.
- Relationship of Hoarding and Depression Symptoms in Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Hoarding Disorder: Development in Conceptualization, Intervention, and Evaluation.Focus (American Psychiatric Publishing) · 2021Article
- Managing hoarding and squalor.Australian prescriber · 2021Review
- Recent Advances in Research on Hoarding.Current psychiatry reports · 2019Review
- Saving inventory - Revised: Psychometric performance across the lifespan.Journal of affective disorders · 2019Article
- Pharmacotherapy for Hoarding Disorder: How did the Picture Change since its Excision from OCD?Current neuropharmacology · 2019Review
- Mapping Compulsivity in the DSM-5 Obsessive Compulsive and Related Disorders: Cognitive Domains, Neural Circuitry, and Treatment.The international journal of neuropsychopharmacology · 2018Review
- Ethical Challenges in Treating Hoarding Disorder: Two Primary Care Clinical Case Studies.Focus (American Psychiatric Publishing) · 2017Article
- Hoarding Disorder: A Case Report.Frontiers in psychiatry · 2017Article
- Acceptability of Treatments and Services for Individuals with Hoarding Behaviors.Journal of obsessive-compulsive and related disorders · 2016Article
- Hoarding disorder in older adulthood.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015Review
- The UCLA Hoarding Severity Scale: development and validation.Journal of affective disorders · 2015Article
- Neuropsychological and neurophysiological insights into hoarding disorder.Neuropsychiatric disease and treatment · 2015Review
- Hoarding disorder: more than just a problem of too much stuff.The Journal of clinical psychiatry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hoarding disorder, classified as a separate disorder in Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5), is a common, chronic, and potentially disabling syndrome that can be difficult to treat. Only one previous study prospectively measured response to pharmacotherapy in compulsive hoarders, finding that hoarders responded as well to paroxetine as did nonhoarding obsessive-compulsive disorder patients. However, paroxetine was not tolerated well in that study, and the overall response was moderate. Therefore, we conducted an open-label trial of venlafaxine extended-release for hoarding disorder. Twenty-four patients fulfilling the DSM-5 criteria for hoarding disorder were treated with venlafaxine extended-release for 12 weeks. All patients were free of psychotropic medications for at least 6 weeks before the study. No other psychotropic medications, cognitive-behavioral therapy, organizers, or cleaning crews were permitted during the study. To measure the severity of hoarding, the Saving Inventory-Revised (SI-R) and the UCLA Hoarding Severity Scale (UHSS) were administered before and after treatment. Twenty-three of the 24 patients completed treatment. Hoarding symptoms improved significantly, with a mean 36% decrease in UHSS scores and a mean 32% decrease in SI-R scores. Sixteen of the 23 completers (70%) were classified as responders to venlafaxine extended-release. These results suggest that venlafaxine extended-release may be effective for the treatment of hoarding disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.