ArticlePloS one2014
MYT3, a Myb-like transcription factor, affects fungal development and pathogenicity of Fusarium graminearum.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Contribution of MylA in Conidiogenesis, Conidia Germination, and beta-Glucan Biosynthesis inJournal of microbiology and biotechnology · 2026Article
- Combining whole genome and transcriptome sequencing to analyze the pathogenic mechanism ofVirulence · 2025Article
- Transcription Factors AsMYB1 and AsMYB3 Regulate Betalain Biosynthesis inJournal of fungi (Basel, Switzerland) · 2025Article
- Production of β-Glucans byInternational journal of molecular sciences · 2025Review
- Whole genome regulatory effect ofmBio · 2024Article
- The MYB-like protein MylA contributes to conidiogenesis and conidial germination in Aspergillus nidulans.Communications biology · 2024Article
- Function of Transcription FactorsInternational journal of molecular sciences · 2023Article
- Herbicide 2,4-dichlorophenoxyacetic acid interferes with MAP kinase signaling in Fusarium graminearum and is inhibitory to fungal growth and pathogenesis.Stress biology · 2023Article
- Genetic and Transcriptional Regulatory Mechanisms of Lipase Activity in the Plant Pathogenic Fungus Fusarium graminearum.Microbiology spectrum · 2023Article
- Transcriptome Profile ofJournal of fungi (Basel, Switzerland) · 2022Article
- The Role of Chromatin and Transcriptional Control in the Formation of Sexual Fruiting Bodies in Fungi.Microbiology and molecular biology reviews : MMBR · 2022Review
- FgSnt1 of the Set3 HDAC complex plays a key role in mediating the regulation of histone acetylation by the cAMP-PKA pathway in Fusarium graminearum.PLoS genetics · 2022Article
- Transcription factor FfMYB15 regulates the expression of cellulase gene FfCEL6B during mycelial growth of Flammulina filiformis.Microbial cell factories · 2022Article
- Role of Dicer-Dependent RNA Interference in Regulating Mycoparasitic Interactions.Microbiology spectrum · 2021Article
- Mating type specific transcriptomic response to sex inducing pheromone in the pennate diatom Seminavis robusta.The ISME journal · 2021Article
- Characterization of the MYB Genes Reveals Insights Into Their Evolutionary Conservation, Structural Diversity, and Functional Roles inFrontiers in microbiology · 2021Article
- FgHtf1 Regulates Global Gene Expression towards Aerial Mycelium and Conidiophore Formation in the Cereal Fungal Pathogen Fusarium graminearum.Applied and environmental microbiology · 2020Article
- Comparative Genomic Analysis of Capsule-Producing Black YeastsFrontiers in microbiology · 2020Article
- Genetic analyses of nitrogen assimilation enzymes in Brassica juncea (L.) Czern & Coss.Molecular biology reports · 2019Article
- The Duality of the MAPK Signaling Pathway in the Control of Metabolic Processes and Cellulase Production in Trichoderma reesei.Scientific reports · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
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Abstract
We previously characterized members of the Myb protein family, MYT1 and MYT2, in Fusarium graminearum. MYT1 and MYT2 are involved in female fertility and perithecium size, respectively. To expand knowledge of Myb proteins in F. graminearum, in this study, we characterized the functions of the MYT3 gene, which encodes a putative Myb-like transcription factor containing two Myb DNA-binding domains and is conserved in the subphylum Pezizomycotina of Ascomycota. MYT3 proteins were localized in nuclei during most developmental stages, suggesting the role of MYT3 as a transcriptional regulator. Deletion of MYT3 resulted in impairment of conidiation, germination, and vegetative growth compared to the wild type, whereas complementation of MYT3 restored the wild-type phenotype. Additionally, the Δmyt3 strain grew poorly on nitrogen-limited media; however, the mutant grew robustly on minimal media supplemented with ammonium. Moreover, expression level of nitrate reductase gene in the Δmyt3 strain was decreased in comparison to the wild type and complemented strain. On flowering wheat heads, the Δmyt3 strain exhibited reduced pathogenicity, which corresponded with significant reductions in trichothecene production and transcript levels of trichothecene biosynthetic genes. When the mutant was selfed, mated as a female, or mated as a male for sexual development, perithecia were not observed on the cultures, indicating that the Δmyt3 strain lost both male and female fertility. Taken together, these results demonstrate that MYT3 is required for pathogenesis and sexual development in F. graminearum, and will provide a robust foundation to establish the regulatory networks for all Myb-like proteins in F. graminearum.
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