ArticlePlant physiology2014
A Positive Regulator of Nodule Organogenesis, NODULE INCEPTION, Acts as a Negative Regulator of Rhizobial Infection in Lotus japonicus.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 94 citations in OpenAlex.
- PUCHI delimits the spatial domain of nodule organogenesis associated with auxin patterning and NIN-dependent transcription in Lotus japonicus.Journal of plant research · 2026Article
- Molecular cartography of root nodule organogenesis: insights into the role of transcription factors.Plant molecular biology · 2026Review
- Transcriptomic Analysis Reveals the Role ofPlants (Basel, Switzerland) · 2026Article
- RHD6LA regulates root hair responses to both symbionts and commensals.Nature communications · 2026Article
- The root nodule symbiosis regulator NIN exhibits broad DNA binding specificity conferred by an NLP-inherited motif.Science advances · 2026Article
- A novel cis-element enabled bacterial uptake by plant cells.Nature plants · 2026Article
- Nodule-specificaBIOTECH · 2025Article
- Applying conventional and cell-type-specific CRISPR/Cas9 genome editing in legume plants.aBIOTECH · 2025Review
- Molecular Insights into the Positive Role of Soybean Nodulation by GmWRKY17.International journal of molecular sciences · 2025Article
- Article
- Conserved cis-elements enable NODULES WITH ACTIVATED DEFENSE1 regulation by NODULE INCEPTION during nodulation.The Plant cell · 2024Article
- Gibberellin dynamics governing nodulation revealed using GIBBERELLIN PERCEPTION SENSOR 2 in Medicago truncatula lateral organs.The Plant cell · 2024Article
- Root nodule organogenesis: a unique lateral organogenesis in legumes.Breeding science · 2023Article
- The putative transporter MtUMAMIT14 participates in nodule formation in Medicago truncatula.Scientific reports · 2023Article
- NIN-at the heart of NItrogen-fixing Nodule symbiosis.Frontiers in plant science · 2023Review
- Temporal change in chromatin accessibility predicts regulators of nodulation in Medicago truncatula.BMC biology · 2022Article
- Right time, right place: The dynamic role of hormones in rhizobial infection and nodulation of legumes.Plant communications · 2022Review
- Innovation and appropriation in mycorrhizal and rhizobial Symbioses.The Plant cell · 2022Article
- Nitrate transport via NRT2.1 mediates NIN-LIKE PROTEIN-dependent suppression of root nodulation in Lotus japonicus.The Plant cell · 2022Article
- Auxin methylation byProceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legume-rhizobium symbiosis occurs in specialized root organs called nodules. To establish the symbiosis, two major genetically controlled events, rhizobial infection and organogenesis, must occur. For a successful symbiosis, it is essential that the two phenomena proceed simultaneously in different root tissues. Although several symbiotic genes have been identified during genetic screenings of nonsymbiotic mutants, most of the mutants harbor defects in both infection and organogenesis pathways, leading to experimental difficulty in investigating the molecular genetic relationships between the pathways. In this study, we isolated a novel nonnodulation mutant, daphne, in Lotus japonicus that shows complete loss of nodulation but a dramatically increased numbers of infection threads. Characterization of the locus responsible for these phenotypes revealed a chromosomal translocation upstream of NODULE INCEPTION (NIN) in daphne. Genetic analysis using a known nin mutant revealed that daphne is a novel nin mutant allele. Although the daphne mutant showed reduced induction of NIN after rhizobial infection, the spatial expression pattern of NIN in epidermal cells was broader than that in the wild type. Overexpression of NIN strongly suppressed hyperinfection in daphne, and daphne phenotypes were partially rescued by cortical expression of NIN. These observations suggested that the daphne mutation enhanced the role of NIN in the infection pathway due to a specific loss of the role of NIN in nodule organogenesis. Based on these results, we provide evidence that the bifunctional transcription factor NIN negatively regulates infection but positively regulates nodule organogenesis during the course of the symbiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.