ReviewPLoS pathogens2014
Cryptosporidium,Giardia, Cryptococcus, Pneumocystis genetic variability: cryptic biological species or clonal near-clades?
Review in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Host range expansion of asexual parasite can be explained by loss of adaptions in Muller's Ratchet.Nature communications · 2025Article
- Tau-typing: a Nextflow pipeline for finding the best phylogenetic markers in the genome for molecular typing of microbial species.Bioinformatics (Oxford, England) · 2023Article
- Subspecific Nomenclature ofPathogens (Basel, Switzerland) · 2023Article
- Population genomics reveals historical and ongoing recombination in theStudies in mycology · 2021Article
- Hidden Diversity within Common Protozoan Parasites as Revealed by a Novel Genomotyping Scheme.Applied and environmental microbiology · 2021Article
- Sexual reproduction in a natural Trypanosoma cruzi population.PLoS neglected tropical diseases · 2019Article
- Multilocus Sequence Typing and Population Genetic Analysis ofFrontiers in genetics · 2019Article
- Clone-based haplotyping of Giardia intestinalis assemblage B human isolates.Parasitology research · 2019Article
- Article
- Advances in Cryptococcus genomics: insights into the evolution of pathogenesis.Memorias do Instituto Oswaldo Cruz · 2018Review
- Relevant units of analysis for applied and basic research dealing with neglected transmissible diseases: The predominant clonal evolution model of pathogenic microorganisms.PLoS neglected tropical diseases · 2017Review
- Clonal Evolution of Enterocytozoon bieneusi Populations in Swine and Genetic Differentiation in Subpopulations between Isolates from Swine and Humans.PLoS neglected tropical diseases · 2016Article
- The population genetics of Trypanosoma cruzi revisited in the light of the predominant clonal evolution model.Acta tropica · 2015Article
- Evidence and importance of genetic exchange among field populations of Trypanosoma cruzi.Acta tropica · 2015Article
- Clonal reproduction in fungi.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Clonality and intracellular polyploidy in virus evolution and pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An abundant literature dealing with the population genetics and taxonomy of Giardia duodenalis, Cryptosporidium spp., Pneumocystis spp., and Cryptococcus spp., pathogens of high medical and veterinary relevance, has been produced in recent years. We have analyzed these data in the light of new population genetic concepts dealing with predominant clonal evolution (PCE) recently proposed by us. In spite of the considerable phylogenetic diversity that exists among these pathogens, we have found striking similarities among them. The two main PCE features described by us, namely highly significant linkage disequilibrium and near-clading (stable phylogenetic clustering clouded by occasional recombination), are clearly observed in Cryptococcus and Giardia, and more limited indication of them is also present in Cryptosporidium and Pneumocystis. Moreover, in several cases, these features still obtain when the near-clades that subdivide the species are analyzed separately ("Russian doll pattern"). Lastly, several sets of data undermine the notion that certain microbes form clonal lineages simply owing to a lack of opportunity to outcross due to low transmission rates leading to lack of multiclonal infections ("starving sex hypothesis"). We propose that the divergent taxonomic and population genetic inferences advanced by various authors about these pathogens may not correspond to true evolutionary differences and could be, rather, the reflection of idiosyncratic practices among compartmentalized scientific communities. The PCE model provides an opportunity to revise the taxonomy and applied research dealing with these pathogens and others, such as viruses, bacteria, parasitic protozoa, and fungi.
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