ArticlePloS one2014
Estimation of the relative sensitivity of qPCR analysis using pooled samples.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Epidemiological surveillance of canine visceral leishmaniasis in a municipality in the Western Amazon.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Development of a Multiplex Real-Time PCR to DisambiguateCurrent issues in molecular biology · 2024Article
- Experimental Infection of Domestic Pigs (Viruses · 2023Article
- Optimizing noninvasive sampling of a zoonotic bat virus.Ecology and evolution · 2021Article
- High Prevalence and Factors Associated With the Distribution of the IntegronFrontiers in veterinary science · 2021Article
- Optimization of group size in pool testing strategy for SARS-CoV-2: A simple mathematical model.Journal of medical virology · 2020Article
- Simulation of pooled-sample analysis strategies for COVID-19 mass testing.Bulletin of the World Health Organization · 2020Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high sensitivity of qPCR makes it a desirable diagnostic method in epidemiological surveillance programs. However, due to high costs, the use of pooling has been suggested. In this paper, an algorithm based on the Montecarlo method has been designed and implemented. The algorithm had been tested in many different situations, and finally it was validated with a real dataset. Moreover, based on the results obtained and depending on pooling conditions, a drastic decrease of sensitivity is observed.
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Registered trials
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